High-Grade Gliomas (eBook)

Diagnosis and Treatment

Gene H. Barnett (Herausgeber)

eBook Download: PDF

2007 | 2007
XIII, 495 Seiten
Humana Press (Verlag)
978-1-59745-185-7 (ISBN)

Infos

This is truly an exciting time in the field of neuro-oncology, particularly in the area of hi- grade gliomas. The management of patients with high-grade gliomas has historically been one of the most challenging and disheartening fields in medicine, where failure is the rule and longevity is the exception. The jaded often state that despite purported advances in surgical and radiotherapeutic techniques and a myriad of clinical trials of medical therapies, the s- vival statistics for glioblastoma have not changed in the last three decades. The nihilism associated with these tumors is such that some practitioners still advise against treatment or even biopsy, recommending palliative care with the diagnosis based only on history and an MRI scan. If the current state-of-the-art in the diagnosis and management of high-grade gliomas was truly so bleak, there would be no reason to compile and publish a monograph on the subject. The fact is that we have recently entered an era where real progress is being made in our understanding and treatment of high-grade gliomas that is directly benefiting some patients. We are slowly but surely chipping away at this problem. One approach has exploited correlations between particular molecular markers and therapeutic response. The first such 'breakthrough' in high-grade glioma was the observation that loss of chromosomes 1p and 19q uniformly predict chemosensitivity in anaplastic oligodendrogliomas (1).

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This is truly an exciting time in the field of neuro-oncology, particularly in the area of hi- grade gliomas. The management of patients with high-grade gliomas has historically been one of the most challenging and disheartening fields in medicine, where failure is the rule and longevity is the exception. The jaded often state that despite purported advances in surgical and radiotherapeutic techniques and a myriad of clinical trials of medical therapies, the s- vival statistics for glioblastoma have not changed in the last three decades. The nihilism associated with these tumors is such that some practitioners still advise against treatment or even biopsy, recommending palliative care with the diagnosis based only on history and an MRI scan. If the current state-of-the-art in the diagnosis and management of high-grade gliomas was truly so bleak, there would be no reason to compile and publish a monograph on the subject. The fact is that we have recently entered an era where real progress is being made in our understanding and treatment of high-grade gliomas that is directly benefiting some patients. We are slowly but surely chipping away at this problem. One approach has exploited correlations between particular molecular markers and therapeutic response. The first such "e;breakthrough"e; in high-grade glioma was the observation that loss of chromosomes 1p and 19q uniformly predict chemosensitivity in anaplastic oligodendrogliomas (1).

Inhalt

Preface 6
Contents 8
Contributors 10
I CLASSIFICATION OF HIGH-GRADE GLIOMA 14
1 Histologic Classification of High-Grade Gliomas 15
2 Molecular Classifications 48
II CLINICAL CHARACTERISTICS 54
3 Pediatric High-Grade Glioma 55
4 Adult High-Grade Glioma 69
III DIAGNOSTIC TOOLS FOR HIGH-GRADE GLIOMA 80
5 Computerized Tomography 81
6 Magnetic Resonance Imaging 113
7 Magnetic Resonance Spectroscopy 141
8 Imaging Tumor Biology 149
9 Nuclear Imaging of Gliomas 168
10 Magnetoencephalography 194
IV MANAGEMENT 203
11 General Considerations 204
12 Surgical Techniques 217
13 Radiation Therapy 235
14 Brachytherapy 249
15 Radiosurgery 261
16 Chemotherapy 271
17 Nursing Considerations 287
V CONTEMPORARY INVESTIGATIONAL TREATMENTS 305
18 Convection-Enhanced Delivery 306
19 Immunotoxins for Glioma Therapy* 318
20 Small Molecule Agents 339
21 Cytokine Immuno-Gene Therapy for Malignant Brain Tumors 359
22 Monoclonal Antibodies 375
23 Clinical Trials of Oncolytic Viruses for Gliomas 392
24 Biological Modifiers 405
25 Gene Therapy 418
26 Boron Neutron Capture Therapy of Brain Tumors 430
27 Photodynamic Therapy 459
Index 483

Produkt-Details

• Erscheint lt. Verlag: 21.11.2007
• Reihe/Serie: Current Clinical Oncology
• Reihe/Serie: Current Clinical Oncology
• Zusatzinfo: XIII, 495 p.
• Verlagsort: Totowa
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Chirurgie ► Neurochirurgie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Schlagworte: Brachytherapy • Chemotherapie • classification • Glioma • Imaging techniques • radiosurgery • Surgery
• ISBN-10: 1-59745-185-1 / 1597451851
• ISBN-13: 978-1-59745-185-7 / 9781597451857