TNF-alpha Inhibitors (eBook)

Jeffrey M. Weinberg, Robin Buchholz (Herausgeber)

eBook Download: PDF

2006 | 2006
X, 133 Seiten
Springer Basel (Verlag)
978-3-7643-7438-9 (ISBN)

Infos

This volume provides a comprehensive overview of the development, pharmacology, efficacy, and safety of the currently available TNF-alpha inhibitors. It is the first volume that summarizes this material for all available TNF-alpha inhibitors. Elevated levels of TNF-alpha have been demonstrated in Crohn's disease, psoriasis, psoriatic arthritis, and rheumatoid arthritis, suggesting a role for TNF-alpha in their pathogenesis. The most recent preclinical and clinical data is presented in this book.

Inhalt

Contents 5
List of contributors 6
Preface 8
Introduction to TNF/pathophysiology of TNF 9
History of development of TNF inhibitors 17
Pharmacology of TNF inhibitors 31
Etanercept in rheumatology 53
Etanercept in dermatology and off-label use 63
Infliximab in rheumatology 72
Infliximab in dermatology, gastroenterology, and off- label use 89
Adalimumab in rheumatology 106
Adalimumab in dermatology 111
A review of the safety of the tumor necrosis inhibitors infliximab, etanercept, and adalimumab 119
Index 132

Produkt-Details

• Erscheint lt. Verlag: 8.8.2006
• Reihe/Serie: Milestones in Drug Therapy
• Reihe/Serie: Milestones in Drug Therapy
• Zusatzinfo: X, 133 p. 10 illus.
• Verlagsort: Basel
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Rheumatologie
• Themenwelt: Medizin / Pharmazie ► Studium
• Schlagworte: Adalimumab • Arthritis • Etanercept • Infliximab • Inhibitors • pathophysiology • pharmacology • Physiology
• ISBN-10: 3-7643-7438-1 / 3764374381
• ISBN-13: 978-3-7643-7438-9 / 9783764374389