Hemostasis and Thrombosis
Lippincott Williams and Wilkins (Verlag)
978-1-60831-906-0 (ISBN)
Since publication of the First Edition in 1982, Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders.
No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians.
This comprehensive resource details the essentials of bleeding and thrombotic disorders and the management of patients with these and related problems, and delivers the most up-to-date information on normal biochemistry and function of platelets or endothelial cells, as well as in-depth discussions of the pharmacology of anticoagulant, fibrinolytic, and hemostatic drugs.
NEW to the Sixth Edition…
- A new team of editors, each a leader in his field, assures you of fresh, authoritative perspectives.
- Full color throughout
- A companion website that offers full text online and an image bank.
- A new introductory section of chapters on basic sciences as related to the field
- Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups.
- Overview chapters preceding each section address broad topics of general importance.
Victor J. Marder MD is Professor of Clinical Medicine, Director, Vascular Medicine Program, Los Angeles Orthopaedic Hospital/UCLA; Division of Hematology/Medical Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Gilbert C. White II MD is Executive Vice President for Research, Blood Center of Wisconsin, Milwaukee, WI.
Sam Schulman MD ist Professor of Medicine, McMaster University, Hamilton, Ontario, Canada.
Joel S. Bennett MD Professor of Medicine, University of Pennsylvania, Philadelphia, PA
William C. Aird MD is Associate Professor of Medicine, Beth Israel Deaconness Medical Center, Boston, MA.
Part 1: Introduction to the Field of Hemostasis and Thrombosis
Chapter 1. History of the Field
William C. Aird and Gilbert C. White, II
Chapter 2. Molecular Evolution of the Vertebrate Blood Coagulation System
Marianne A. Grant and William C. Aird
Chapter 3. Molecular and Clinical Genetics
Lesley Everett, Karl C. Desch, and David Ginsburg
Chapter 4: Coagulation Enzymology
Sriram Krishnaswamy
Chapter 5: Cell Biology, Protein Processing, and Cell Signaling
Randal J. Kaufman and Laura Popolo
Chapter 6: Cellular and Molecular Immunology
Andrew H. Lichtman
Chapter 7: Biostatistics and Epidemiology: The Basic Science of Clinical Research
Kerry L. Lee
PART II: BASIC HEMOSTASIS AND THROMBOSIS
SECTION A: COAGULATION & FIBRINOLYSIS
Chapter 8: Overview of Basic Coagulation and Fibrinolysis
Gilbert C. White, II, Victor J. Marder, Sam Schulman, William C. Aird, and Joel S. Bennett
Chapter 9: The Blood Coagulation Factors and Inhibitors: Complementary DNAs, Genes and Expression
Dominic W. Chung, Wengfeng Xu, and Earl W. Davie
Chapter 10: Genetics of Coagulation Proteins
Rodney M. Camire and Paris Margaritis
Chapter 11: Tissue Factor and the Initiation and Regulation (TFPI) of Coagulation
George J. Broze, Jr. and James H. Morrissey
Chapter 12: Factors V and VIII
Randal J. Kaufman, Philip J. Fay, Laura Popolo, and Thomas L. Ortel
Chapter 13: Structure and Function of von Willebrand Factor
Sandra L. Haberichter and Robert R. Montgomery
Chapter 14: Structure and Function of Vitamin K-Dependent Coagulant and Anticoagulant Proteins
Kanagasabai Vadivel, Amy E. Schmidt, Victor J. Marder, Sriram Krishnaswamy, and S. Paul Bajaj
Chapter 15A: Factor XI
Peter N. Walsh and David Gailani
Chapter 15B: The Factor XII-driven Plasma Contact System
Thomas Renne
Chapter 16: Fibrinogen Structure and Function
John W. Weisel and Carl-Erik Dempfle
Chapter 17: Factor XIII
Cédric Duval, Helen Philippou, and Robert A. S. Ariëns
Chapter 18: Antithrombin and the Serpin Family
Susan C. Bock
Chapter 19: Protein C and S and Thrombomodulin System
Laurent O. Mosnier and John H. Griffin
Chapter 20: Plasminogen Activation and Regulation of Fibrinolysis
Nuala A. Booth and Nicola J. Mutch
Chapter 21: Inhibitors of Fibrinolysis
Björn Wiman and Anna Ågren
SECTION B: PLATELET BIOLOGY
Chapter 22: Overview of Platelet Structure and Function
Joel S. Bennett and Gilbert C. White, II
Chapter 23: Platelet Production: Cellular and Molecular Regulation
Elisabeth Cramer Bordé and William Vainchenker
Chapter 24: Megakaryocyte Structure and Platelet Biogenesis
Joseph E. Italiano, Jr. and John H. Hartwig
Chapter 25: Thrombopoietin
Kenneth Kaushansky and Ian Hitchcock
Chapter 26A: Major Platelet Glycoproteins: GPIb-IX-V
Michael C. Berndt, and Robert K. Andrews
Chapter 26B: Major Platelet Glycoproteins: GPIIb/IIIa
Feng Ye and Mark H. Ginsberg
Chapter 27: Platelet Glycoprotein Polymorphisms and Relationship to Function and Immunogenicity
Thomas J. Kunicki and Diane J. Nugent
Chapter 28: The Basis for Platelet Adhesion
Brian Savage and Zaverio M. Ruggeri
Chapter 29: Shear Effects on Platelets and the Vessel Wall in the Pathogenesis of Atherothrombosis
David L. Bark Jr., Warwick S. Nesbitt, Angus K.T. Wong, and Shaun P. Jackson
Chapter 30: Platelets and Collagen
Steve P Watson, Richard W Farndale, Masaaki Moroi, and Stephanie M Jung
Chapter 31: Integrin αIIb β3 and Platelet Aggregation
Ana Kasirer-Friede, Kamila Bledzka, Jun Qin, , Edward F. Plow, and Sanford J. Shattil
Chapter 32: Molecular Basis for Platelet Secretion
Shaojing Ye and Sidney W. Whitehart
Chapter 33: Platelet Signal Transduction
Charles S. Abrams and Lawrence F. Brass
Chapter 34: Platelet Prostaglandin Metabolism
Tilo Grosser and Garret A. FitzGerald
Chapter 35: The Role of Platelets in Blood Coagulation
Peter N. Walsh
Chapter 36: Blood-Borne Microparticles
José López and Swaminathan Murugappan
SECTION C: VASCULAR BIOLOGY
William C. Aird
Chapter 37: Overview of Vascular Biology
William C. Aird
Chapter 38: Development of the Vasculature, Angiogenesis, Lymphangiogenesis
Aernout Luttun and Peter Carmeliet
Chapter 39: Rheology and Vessel Wall Stress
Peter F. Davies, Larry V. McIntire, and Juan M. Jiménez
Chapter 40: Nitric Oxide
Bradley A. Maron and Thomas Michel
Chapter 41: Blood Vessel Wall in Health and Disease
Keith R. Brunt, Sonya Hui, Jagdish Butany, and Mansoor Husain
Chapter 42: Endothelial Cell Function
William C. Aird
Chapter 43: Role of Endothelium in Hemostasis
Michael J. Krisinger and Edward M. Conway
Chapter 44: Coagulation-Independent Signaling of the Extrinsic Coagulation Pathway
Wolfram Ruf
Chapter 45: Heparin and Vascular Proteoglycans
Douglas M. Tollefsen and Lijuan Zhang
Chapter 46: Endothelial Cell-Blood Cell Interactions
Klaus Ley
Chapter 47: Leukocyte Function and Contribution to Disease
Edith van de Vijver and Taco W. Kuijpers
Chapter 48: Laboratory Markers of Endothelial Cell Activation and Dysfunction
Eduard Shantsila, Gregory Y.H. Lip, and Robert P. Hebbel
PART III: DISORDERS OF COAGULATION, PLATELETS, AND VESSEL WALL
SECTION A: BLEEDING DISORDERS COAGULATION & FIBRINOLYSIS
Chapter 49: Overview of Inherited Hemorrhagic Disorders
Gilbert C. White, II, Harold R. Roberts, and Victor J. Marder
Chapter 50: Differential Diagnosis of the Bleeding Patient
Jill M. Johnsen and Barbara A. Konkle
Chapter 51: Clinical Manifestations and Therapy of Inherited and Acquired Hemophilia
Edward G.D. Tuddenham
Chapter 52: von Willebrand Disease: Diagnosis, Classification, and Treatment
J. Evan Sadler and David Lillicrap
Chapter 53: Rare Inherited Coagulation Disorders Other than Hemophilia
Pier Mannuccio Manucci, Massimo Franchini, and Flora Peyvandi
Chapter 54: Afibrogenemias and Dysfibrogenemias
Dennis K. Galanakis
Chapter 55: Familial Multiple Coagulation Factor Deficiencies
Bin Zhang and David Ginsburg
Chapter 56: Clinical Disorders of Fibrinolysis
Daphne Stewart, Charles W. Francis, and Victor J. Marder
Chapter 57: Acquired Disorders of Coagulation: The Immune Coagulopathies
Charles RM Hay
Chapter 58: Laboratory Markers of Coagulation and Fibrinolysis
Kenneth A. Bauer and Helen A. Ireland
SECTION B: ACQUIRED & INHERITED PLATELET DISORDERS
Chapter 59: Overview of Acquired and Inherited Clinical Platelet Disorders
Joel S. Bennett
Chapter 60: Differential Diagnosis of Thrombocytopenia
Joel S. Bennett and Charles S. Abrams
Chapter 61: Immune Thrombocytopenic Purpuraand Posttransfusion Purpura
Howard A. Liebman, Douglas B. Cines, and James B. Bussel
Chapter 62: Drug-Induced Thrombocytopenia
Richard H. Aster and James N. George
Chapter 63: Inherited Thrombocytopenias
Paquita Nurden and Alan T. Nurden
Chapter 64: Acquired Nonimmune Thrombocytopenia
Andreas Greinacher and Theodore E. Warkentin
Chapter 65: Hereditary Disorders of Platelet Function
Joel S. Bennett and A. Koneti Rao
Chapter 66: Acquired Disorders of Platelet Function
A. Koneti Rao and Joel S. Bennett
Chapter 67: Laboratory Markers of Platelet Activation
Paul Harrison and Alan D. Michelson
SECTION C: PRIMARY DISORDERS OF BLOOD VESSELS
Chapter 68: Overview of Primary Disorders of Blood Vessels
William C. Aird
Chapter 69: Disorders of Connective Tissue and Extracellulara Matrix
Fransiska Malfait and Anne dePaepeChapter 70: Hereditary Hemorrhagic Telangiectasia
Michelle Letarte and Claire L. Shovlin
Chapter 71: Arteriovenous Malformations and Hemangiomas and Cerebral Cavernous Malformations
Douglas A. Marchuk and Mark L. Kahn
Chapter 72: Aneurysms (Large and Small Arteries)
Carlos E. Sanchez, Sangita Kapur, and Neal L. Weintraub
Chapter 73: Intracranial Hemorrhage
Timolaos Rizos and Thorsten Steiner
Chapter 74: Retinopathy
Jing Chen, , Andreas Stahl, and Lois E.H. Smith
SECTION D: THERAPY OF BLEEDING DISORDERS
Chapter 75: Overview to Therapy of Bleeding Disorders
Gilbert C. White II
Chapter 76: Management of Acute Hemorrhage
Nigel S. Key, Micah J. Mooberry, and Rommer Lu
Chapter 77: Therapy with Antifibrinolytic Agents
Daphne B. Stewart and Victor J. Marder
Chapter 78: Transfusion Medicine
Thomas S. Kickler
Chapter 79: New Approaches for the Therapy of Bleeding Disorders, Including Gene Therapy
Gilbert C. White II and Harold R. Roberts
PART IV: THROMBOTIC DISORDERS
SECTION A: VENOUS THROMBOTIC DISORDERS
Chapter 80. Overview of Venous Thromboembolism
Sam Schulman, Victor J. Marder, and Gilbert C. White II
Chapter 81: Thrombophilia Genetics
Joseph Emmerich, Martine Aiach, and Pierre-Emmanuel Morange
Chapter 82: Epidemiology and Risk Factors of Venous Thromboembolism
John A. Heit
Chapter 83: Clinical Manifestations and Diagnosis of Venous Thromboembolism
Henri Bounameaux and Arnaud Perrier
Chapter 84: Venous Thrombosis in Unusual Sites
Victor J. Marder, Hylton V. Joffe, and Sam Schulman
Chapter 85: Sequelae of Venous Thromboembolic Disease: Postthrombotic Syndrome and Chronic Thromboembolic Pulmonary Hypertension
Vittorio Pengo and Susan R. Kahn
Chapter 86: Prevention of Venous Thromboembolic Disease
Menno V. Huisman, Ajay Kakkar, Pasha, and Patrick Mismetti
Chapter 87: Treatment of Venous Thromboembolic Disease
Sam Schulman, Jeffrey Ginsberg, and James Douketis
SECTION B: ARTERIAL THROMBOTIC DISORDERS
Chapter 88: Overview of Arterial Thrombotic Disorders
Sam Schulman and Victor J. Marder
Chapter 89: Pathophysiology of Atherosclerosis
Peter Libby, Paul M. Ridker, and Kevin Croce
Chapter 90: Acute Coronary Syndromes: Manifestations and Management
John Paul Vavalle, John H. Alexander, and Matthew T. Roe
Chapter 91: Pathophysiology of Thromboembolic Stroke
Emer R. McGrath and Martin J. O'Donnell
Chapter 92: Prevention of Thromboembolic Stroke in Patients with Atrial Fibrillation, Valvular Heart Disease, Cardiomyopathy
Thomas Kawano and Jonathan L. Halperin
Chapter 93: Acute Stroke: General Management, Anticoagulant, and Thrombolytic Therapy
Gregory J. del Zoppo and Jeffrey L. Saver
Chapter 94: Medical and Surgical Treatment of Peripheral Arterial Disease
Phillip Joseph, Saurabh Kalra, and Sonia Anand
Chapter 95: Unusual Sites of Arterial Occlusion
Philip A. Kalra, Jon G. Moss, and Peter Wiedemann
Chapter 96: Pathogenesis and Treatment of Biomaterial-Associated Thrombosis
Maud B. Gorbet and Michael V. Sefton
SECTION C: COMPLEX THROMBOTIC DISORDERS
Chapter 97: Overview of Microvascular and Complex Thrombotic Disorders
Theodore E. Warkentine and Victor J. Marder
Chapter 98: Consumptive Thrombohemorrhagic Disorders
Marcel Levi, Donald I. Feinstein, Robert W. Colman, and Victor J. Marder
Chapter 99: Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome-Microangiopathies
George
Chapter 100: Vasculitides
James R. Stone and John H. Stone
Chapter 101: Antiphospholipid Antibodies and the Antiphospholipid Syndrome
Jacob H. Rand and Lucia R. Wolgast
Chapter 102: Thrombohemorrhagic Complications of Myeloproliferative Disorders
Ayalew Tefferi
Chapter 103: Thrombotic and Hemorrhagic Complications Associted with Stem Cell Transplantation
Yona Nadir and Benjamin Brenner
SECTION D: THERAPEUTIC AGENTS
Chapter 104: Overview of Therapeutic Agents used in Thrombotic Disorders
Sam Schulman and Victor J. Marder
Chapter 105: Pharmacology and Mode of Action of Heparin and Glycosaminoglycans
Meyer Michael Samama, Jeanine M. Walenga, Evi Kalodiki, and Jawed Fareed
Chapter 106: Vitamin K Antagonists: Biochemistry, Pharmacology and Management
Nirmish Shah, Thomas L. Ortel, and Sam Schulman
Chapter 107: Hemorrhagic Complications of Anticoagulation
Sam Schulman and Mark A. Crowther
Chapter 108: Heparin-Induced Thrombocytopenia
Theodore E. Warkentin and Andreas Greinacher
Chapter 109: Coumarin-Induced Skin Necrosis and Venous Limb Gangrene
Theodore E. Warkentin
Chapter 110: New Antithrombotic Drugs
Jeffrey I. Weitz and Peter L. Gross
Chapter 111: Antiplatelet Therapy
Carlo Patrono
Chapter 112: Thrombolytic Therapy
Victor J. Marder and Daphne B. Stewart
Chapter 113: Anticoagulant and Procoagulant Proteinsin the Animal Kingdom
Angelina Wei Ling Tan, Shiyang Kwong, and R. Manjunatha Kinia
Chapter 114: Mechanical Devices and Embolectomy
Hervé Decousus, Patrick Mismetti, and Nicolas Meneveau
PART V:Hemostatic and Thrombotic Disorders Associated with Systemic Conditions
Chapter 115: Overview of Special Clinical Groups
Victor J. Marder
Chapter 116: VTE during Pregnancy and with Hormonal Contraceptives
Saskia Middeldorp, Mathilde Nijkeuter, and Michiel Coppens
Chapter 117: Gestational Vascular Complications
Benjamin Brenner, Anat Aharon, Jean-Christophe Gris
Chapter 118: Maternal Hemostatic Disorders and Obstetric Hemorrhage
Philippe De Moerloose, Françoise Boehlen, and Jean Christophe Gris
Chapter 119: Developmental Hemostasis
Paul Monagle, Vera Ignatovic, and Leslie Roy Berry
Chapter 120: Bleeding in Neonates and Children
Anthony K. Chan, Elizabeth A. Chalmers, Sam Schulman, and Alan Michelson
Chapter 121: Venous and Arterial Thromboembolism in Children
Paul Monagle, M. Patricia Massicotte, and Anthony K. Chan
Chapter 122: Thrombotic Complications of Sickle Cell Disease
Kenneth I. Ataga and Elliott P. Vichinsky
Chapter 123: Thrombohemorrhagic Complications of Sepsis
Marcel Levi
Chapter 124: Hemorrhagic Fevers: Epidemiology, Pathophysiology, and Clinical Features
Gayani Tillekeratne, Jennifer Cohn, and Hillary Dunlevy
Chapter 125: Cancer-related Thrombosis
Anna Falanga, Agnes Y. Y. Lee, Frederick R. Rickles
Chapter 126: Hemostatic Abnormalities in Liver Disease
Charles S. Eby and Stephen H. Caldwell
Chapter 127: Hemostatic Abnormalities in Renal Disease
Miriam Galbusera, Giuseppe Remuzzi, and Patrizia Ondei
Chapter 128: Multtrauma Derangements in Hemostasis and Thrombosis
Diane A. Schwartz, Lucy Z. Kornblith, John B. Holcomb, and Mitchell Jay Cohen
Chapter 129: Blood Management in the Cardiovascular Surgery Patient
Lawrence Tim Goodnough and L. Henry Edmunds Jr.
Chapter 130: Thrombo-Hemorrhagic Events in the Elderly
Isabelle Mahe and Ludovic Drouet
| Erscheint lt. Verlag | 4.12.2012 |
|---|---|
| Zusatzinfo | Illustrations |
| Verlagsort | Philadelphia |
| Sprache | englisch |
| Maße | 277 x 213 mm |
| Gewicht | 3881 g |
| Einbandart | gebunden |
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Hämatologie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
| ISBN-10 | 1-60831-906-7 / 1608319067 |
| ISBN-13 | 978-1-60831-906-0 / 9781608319060 |
| Zustand | Neuware |
| Haben Sie eine Frage zum Produkt? |
aus dem Bereich
