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Antibiotic Discovery and Development

Thomas J. Dougherty, Michael J. Pucci (Herausgeber)

Buch | Hardcover

1127 Seiten

2011
Springer-Verlag New York Inc.
978-1-4614-1399-8 (ISBN)

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This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.

Introductory History of Antimicrobial Drugs.- Marketed Major Classes of Compounds.- The Rise of Antibiotic Resistance/Resistance Mechanisms to Major Classes.- Clinical Issues of Resistance: “Worst Offenders” List of Problematic Microbes.- Antibiotic Discovery.- Antibiotic Drug Development.- The Economics and Incentives of Antibiotic Drug Discovery.

Zusatzinfo	XVII, 1127 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Naturwissenschaften ► Chemie ► Physikalische Chemie
ISBN-10	1-4614-1399-0 / 1461413990
ISBN-13	978-1-4614-1399-8 / 9781461413998
Zustand	Neuware