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Redox Regulation of Cell Signaling and Its Clinical Application -

Redox Regulation of Cell Signaling and Its Clinical Application

Junji Yodoi (Herausgeber)

Buch | Hardcover
344 Seiten
1999
Crc Press Inc (Verlag)
978-0-8247-1961-6 (ISBN)
CHF 429,95 inkl. MwSt
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Presents recent developments in the rapidly expanding field of redox regulation research. The book examines insights into intracellular communication and new techniques for diagnosing and treating diseases associated with oxidation and reduction. It focuses on important cellular mechanisms, such as redox reactions related to thioredoxin (TRX)/adult T-cell leukemia-derived factor (ADF).

Junji Yodoi

Thioredoxin/adult t-cell leukaemia-derived factor (ADF) and redox regulation; dysfunction of redox system by reactive oxygen and nitrogen species; redox regulation of glucocorticoid hormone action - cross-talk between endocrine stress response and cellular antioxidant system; oxidative stress by tumor-derived macrophages induces abnormal structure of t-cell receptor complex; structural basis of thioredoxin-mediated redox regulation; regulation of yAP-1 nuclear localization in response to oxidative stress; a novel antioxidant enzyme, thioredoxin peroxidase and mammalian peroxiredoxins; protective action of adult T cell leukaemia derived factor (ADF)/thioredoxin (TRX) against oxidative damage in the kidney of mice treated with a renal carcinogen, ferric nitrilotriacetate - induction and nuclear translocation of ADF/TRX; cellular response to lipid peroxidation products; primary involvement of oxidative damage and redox imbalance in Alzheimer and other neurodegenerative diseases; roles of Syk protein tyrosine kinase in stress-induced signalling in B cells; redox regulation of the DNA binding activity in transcription factor PEBP2 - the roles of two conserved cysteine residues; reactive oxygen enhanced EGF receptor phosphorylation; redox-oriented chemical events in signal transduction in cells; mammalian peroxiredoxin MSP23 as an oxidative stress-inducible protein; implication of oxidative stress induced in long term uremic complication; thioredoxin - a regulatory protein with potential application in medicine and technology; the elevated serum level of thioredoxin in patients with chronic and/or malignant liver diseases; AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1; oxygen radicals, redox regulation of the NF-kB signalling and disease control by antioxidants; redox regulation of protein function by thioredoxin and glutaredoxin systems; therapeutic potential of alpha-lipoic acid - molecular aspects.

Reihe/Serie Oxidative Stress and Disease
Verlagsort Bosa Roca
Sprache englisch
Maße 210 x 280 mm
Gewicht 635 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete
Studium 1. Studienabschnitt (Vorklinik) Histologie / Embryologie
ISBN-10 0-8247-1961-1 / 0824719611
ISBN-13 978-0-8247-1961-6 / 9780824719616
Zustand Neuware
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