Inflammation and Cancer
Humana Press Inc. (Verlag)
978-1-61737-905-5 (ISBN)
According to the most recent clinical oncology data, one out of seven newly diagnosed malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. In Inflammation and Cancer: Methods and Protocols, expert researchers deliver a systematic guide to techniques addressing various aspects of experimental cancer biology, selectively focused on inflammation-mediated tumorigenesis, while promoting improvisations on a per-case basis. Volume 2, Molecular Analysis and Pathways is devoted to an extensive description of experimental strategies aimed at investigating the molecular cross-talks between components of cell signaling chains and their ramifications in diagnostic development and drug target discovery. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their subjects, lists of the necessary materials and reagents, step-by-step laboratory protocols, and a notes section, which examines tips on troubleshooting and avoiding known pitfalls.
Comprehensive and cutting-edge, Inflammation and Cancer: Methods and Protocols promises to serve as a vital guide and resource for investigators and clinicians working toward the goal of combatting the estimated 2, 200 inflammation-related oncogenesis fatalities occurring every day.
Crossroads of Inflammation and Cancer: Molecular Aspects.- Immunohistochemical Analysis of 8-Nitroguanine, A Nitrative DNA Lesion, in Relation to Inflammation-Associated Carcinogenesis.- Molecular Analysis of Genetic Instability Caused by Chronic Inflammation.- Obesity Provides a Permissive Milieu in Inflammation-Associated Carcinogenesis: Analysis of Insulin and IGF Pathways.- Detecting and Modulating the NF-kB Activity in Human Immune Cells: Generation of Human Cell Lines with Altered Levels of NF-?B.- Inflammation-Related Aberrant Patterns of DNA Methylation: Detection and Role in Epigenetic Deregulation of Cancer Cell Transcriptome.- cDNA Microarray Analysis of Inflammatory Breast Cancer Signatures.- Analysis of the TLR/NF-?B Pathway in Antigen-Presenting Cells in Malignancies Promoted by Inflammation.- Induced Nitric Oxide Synthase as a Major Player in the Oncogenic Transformation of Inflamed Tissue.- Molecular and Cellular Approaches to Diagnostics and Drug Target Discovery In Inflammation-Related Oncogenesis.- Development of a Cell-Based Assay to Quantify the Inflammatory Potential of Test Substances and Screen Compound Libraries for Anti-cancer Drug Candidates in a High-Throughput Format.- The NF-?B Transcription Factor Pathway as a Therapeutic Target in Cancer: Methods for Detection of NF-?B Activity.- Inhibiting Proinflammatory NF-?B Signaling Using Cell-Penetrating NEMO Binding Domain Peptides.- Quantitative Measurement of Cytokine Expression in Synoviocytes Derived from Rheumatoid Arthritis Patients.- Molecular Characterization of Inflammation-Induced JNK/c-Jun Signaling Pathway in Connection with Tumorigenesis.- Molecular Characterization of STAT Signaling in Inflammation and Tumorigenesis.- Inflammation and Tumor Progression: A Lesson fromTNF-?-Dependent FAK Signaling in Cholangiocarcinoma.- Cyclooxygenase Inhibitors Induce Colon Cancer Cell Apoptosis Via PPAR? ? 14-3-3? Pathway.- PPAR?/? Agonist Increases the Expression of PGE2 Receptor Subtype EP4 in Human Lung Carcinoma Cells.- Investigating Macrophage and Malignant Cell Interactions In Vitro.- Cellular Magnetic Resonance Imaging Using Superparamagnetic Anionic Iron Oxide Nanoparticles: Applications to In Vivo Trafficking of Lymphocytes and Cell-Based Anticancer Therapy.- Application of Phage Display to Discovery of Tumor-Specific Homing Peptides: Developing Strategies for Therapy and Molecular Imaging of Cancer.- Molecular Basis of Histone Deacetylase Inhibitors as New Drugs for the Treatment of Inflammatory Diseases and Cancer.- Peptide YY Mediates Inhibition of Tumor Growth and Inflammation.
From the reviews:
“Chapters in this volume are designed to be guides to techniques addressing various aspects of experimental cancer biology. … this volume will earn a place on the lab benches of investigators and clinicians who are studying inflammation-related oncogenesis. … this book can provide a source of information for establishing new techniques as well as suggestions for investigating particular aspects of tumorigenesis.” (Marion C. Cohen, Doody’s Review Service, December, 2009)
| Reihe/Serie | Methods in Molecular Biology ; 512 |
|---|---|
| Zusatzinfo | 51 Illustrations, black and white; XVI, 408 p. 51 illus. |
| Verlagsort | Totowa, NJ |
| Sprache | englisch |
| Maße | 193 x 260 mm |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Laboratoriumsmedizin |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
| Medizin / Pharmazie ► Studium | |
| ISBN-10 | 1-61737-905-0 / 1617379050 |
| ISBN-13 | 978-1-61737-905-5 / 9781617379055 |
| Zustand | Neuware |
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