Percutaneous Absorption
Marcel Dekker Inc (Verlag)
978-0-8247-1966-1 (ISBN)
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Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body.
Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research!
Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details
the applied biology of percutaneous penetration
factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure
in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes
procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue
And presents new chapters on
mathematical models
cutaneous metabolism
prediction of percutaneous absorption
in vitro absorption methodology
dermal decontamination
concentration of chemicals in skin
transdermal drug delivery
mechanisms of absorption
safety evaluation of cosmetics
absorption of drugs and cosmetic ingredients
nail penetration
Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines!
An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.
Mechanisms of absorption: mathematical models in percutaneous absorption; cutaneous metabolism during in vitro percutaneous absorption; cutaneous metabolism of Xenobiotics; occlusion does not uniformly enhance penetration in vivo; regional variationin percutaneous absorption. Methodology: in vivo methods for percutaneous absorption measurements; determination of percutaneous absorption by in vitro techniques; will cutaneous levels of absorbed material be systemically absorbed ; dermaldecontamination and percutaneous absorption; partioning of chemicals from water into powdered human stratum corneum (Callus) - a model study; in vitro percutaneous absorption of model compounds glyphosate and malathion from fabric into and through humanskin; vaginal absorption of prostaglandin E, in rhesus monkey; human cadaver skin viability for in vitro percutaneous absorption - storage and detrimental effects of heat separation and freezing. Drug and cosmetic absorption: percutaneous penetration as amethod of delivery to skin and underlying tissues; phonophoresis; facilitated transdermal delivery by iontophoresis; percutaneous penetration as it relates to the safety evaluation of cosmetic ingredients; percutaneous absorption of fragrances; hair dyeabsorption; percutaneous absorption of alpha-hydroxy acids in human skin; optimizing patch test delivery - a model; permeation of N-nitrosamines through human skin; nail penetration - focus on topical delivery of antifungal drugs for onchomycosistreatment; topical dermatological vehicles - a holistic approach.
| Erscheint lt. Verlag | 28.5.1999 |
|---|---|
| Reihe/Serie | Drugs and the Pharmaceutical Sciences |
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 152 x 229 mm |
| Gewicht | 1315 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Technik | |
| ISBN-10 | 0-8247-1966-2 / 0824719662 |
| ISBN-13 | 978-0-8247-1966-1 / 9780824719661 |
| Zustand | Neuware |
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