Oncogenes

An Introduction to the Concept of Cancer Genes

Kathy B. Burck, Edison T. Liu, James W. Larrick (Autoren)

Buch | Softcover

300 Seiten

1988 | 1st ed. 1988. Corr. 2nd printing
Springer-Verlag New York Inc.
978-0-387-96423-2 (ISBN)

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"Cancer viruses" have played a paradoxical role in the history of cancer research. Discovered in 1911 by Peyton Rous (1) at the Rockefeller Institute, they were largely ignored for several decades. Witness his eventual recognition for a Nobel Prize, but not until 1966-setting an all time record for latency, and testimony to one more advantage of longevity. In the 1950s, another Rockefeller Nobelist, Wendell Stanley, spearheaded a campaign to focus attention on viruses as etiological agents in cancer, his plat form having been the chemical characterization of the tobacco mosaic virus as a pure protein-correction, ribonucleoprotein-in 1935 (2). This doctrine was a centerpiece of the U.S. National Cancer Crusade of 1971: if human cancers were caused by viruses, the central task was to isolate them and prepare vaccines for immunization. At that point, many observers felt that perhaps too much attention was being devoted to cancer viruses. It was problematic whether viruses played an etiological role in more than a handful of human cancers.

1 Introduction.- 2 Assays: Tools of the New Biology.- 3 Viruses and Oncogenes.- 4 Human T Cell Lymphotropic/Leukemia Viruses.- 5 Cellular Proto-oncogenes.- 6 Oncogenes and Human Cancers.- 7 src and Related Protein Kinases.- 8 Growth Factors and Receptors.- 9 ras Family of Oncogenes.- 10 myc and Other Nuclear Oncogenes.- 11 Additional Oncogenes.- 12 Transgenic Mice: Direct In Vivo Assay for Oncogenes.- 13 Potential Diagnostic Uses of Oncogenes.- 14 Potential Therapeutic Applications of Oncogenes.- 15 Oncogene Paradigm: Contribution to a Fundamental Understanding of Malignancy.- Appendix: Oncogenes and Related Genes.

Erscheint lt. Verlag	21.12.1989
Vorwort	Joshua Lederberg
Zusatzinfo	4 Illustrations, color; 33 Illustrations, black and white; XV, 300 p. 37 illus., 4 illus. in color.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
ISBN-10	0-387-96423-1 / 0387964231
ISBN-13	978-0-387-96423-2 / 9780387964232
Zustand	Neuware