Ethnicity in Drug Development and Therapeutics

Edyta J. Frackiewicz, Thomas M. Shiovitz, Stanford S. Jhee (Autoren)

Buch | Softcover

152 Seiten

2011
Cambridge University Press (Verlag)
978-0-521-29252-8 (ISBN)

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This 2002 book presents an overview of ethnic and racial differences in response to medications and offers insight into the genetic and non-genetic reasons for these differences. The roles of pharmacogenomics and pharmacogenetics in drug development and regulatory aspects of representing minorities in clinical trials are examined in detail.

This book was first published in 2002. It presents an overview of ethnic and racial differences in response to medications and offers insight into the genetic and non-genetic reasons for these differences. The roles of pharmacogenomics and pharmacogenetics in drug development, regulatory aspects of representing minorities in clinical trials, as well as NIH, ICH and FDA guidelines as they pertain to these issues are examined in detail. Finally, various strategies to increase recruitment and retention of minority populations in clinical trials are considered.

Foreword; Preface; References; 1. Clinical evidence of ethnic and racial differences in drug pharmacodynamics and pharmacokinetics; 2. Ethnic and racial differences in pharmacokinetics of drug metabolism; 3. Ethnic and racial differences in the pharmacokinetics of drugs: absorption, distribution, elimination; 4. Non-genetic basis for ethnic and racial differences in pharmacokinetic parameters; 5. The impact of pharmacokinetics on drug development; 6. Pharmacokinetic analysis of ethnic groups using population methods; 7. Ethnic representation in clinical research and foreign market penetration: regulatory aspects; 8. Recruitment and retention of minority study volunteers.

Erscheint lt. Verlag	16.6.2011
Zusatzinfo	Worked examples or Exercises
Verlagsort	Cambridge
Sprache	englisch
Maße	156 x 234 mm
Gewicht	230 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
ISBN-10	0-521-29252-2 / 0521292522
ISBN-13	978-0-521-29252-8 / 9780521292528
Zustand	Neuware