TT Viruses

The Still Elusive Human Pathogens

Ethel-Michele De Villiers, Harald Zur Hausen (Herausgeber)

Buch | Softcover

X, 233 Seiten

2010 | 1. Softcover reprint of hardcover 1st ed. 2009
Springer Berlin (Verlag)
978-3-642-08998-5 (ISBN)

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It is not unreasonable to suspect that persistence of at least some specific TT virus genotypes may result in some infected individuals in a definable pathogenicity. The authors believe that this volume provides the first hints in support of this view.

Eleven years ago the circular DNA of a novel single-stranded virus has been cloned and partially characterized by Nishizawa and Okamoto and their colleagues. According to the initials of the patient from whom the isolate originated, the virus was named TT virus. This name has been subsequently changed by the International Committee on Taxonomy of Viruses (ICTV) into Torque teno virus, permitting the further use of the abbreviation TTV. Although initially suspected to play a role in non A -E hepatitis, subsequent studies failed to support this notion.

Within a remarkably short period of time it became clear that TT viruses are widely spread globally, infect a large proportion of all human populations studied thus far and represent an extremely heterogeneous group of viruses, now labelled as Anelloviruses. TT virus-like infections have also been noted in various animal species. The classification of this virus group turns out to be difficult, their DNA contains between 2200 and 3800 nucleotides, related so-called TT-mini-viruses and a substantial proportion of intragenomic recombinants further complicate attempts to combine these viruses into a unifying phylogenetic concept.

History of Discoveries and Pathogenicity of TT Viruses.- Classification of TTV and Related Viruses (Anelloviruses).- TT Viruses in Animals.- Replication of and Protein Synthesis by TT Viruses.- Immunobiology of the Torque Teno Viruses and Other Anelloviruses.- Intragenomic Rearrangement in TT Viruses: A Possible Role in the Pathogenesis of Disease.- TT Viruses: Oncogenic or Tumor-Suppressive Properties?.- Relationship of Torque Teno Virus to Chicken Anemia Virus.- Apoptosis-Inducing Proteins in Chicken Anemia Virus and TT Virus.- Chicken Anemia Virus.- Geminiviruses.

Erscheint lt. Verlag	20.11.2010
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	X, 233 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	374 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Anatomie / Neuroanatomie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	anelloviruses • Apoptosis • chicken anemia virus • classification • geminiviruses • Immunobiology • Infections • proteins • TT Virus • Viruses
ISBN-10	3-642-08998-4 / 3642089984
ISBN-13	978-3-642-08998-5 / 9783642089985
Zustand	Neuware