Cystic Fibrosis
Humana Press Inc. (Verlag)
978-1-61779-119-2 (ISBN)
Comprehensive and practical, Cystic Fibrosis: Diagnosis and Protocols will provide readers with optimal working tools to address pressing questions in the best technical way, while helping all of us, as a research and clinical community, to move faster hand-in-hand toward unravelling the secrets of this challenging disorder and cure it.
Introduction to Part I: Overview of Approaches to Study Cystic Fibrosis Pathophysiology.- Imaging CFTR Protein Localization in Cultured Cells and Tissues.- CFTR Regulation of Epithelial Sodium Channel.- Methods for Evaluating Inflammation in Cystic Fibrosis.- Methods for ASL Measurements and Mucus Transport Rates in Cell Cultures.- Measurement of Fluid Secretion from Intact Airway Submucosal Glands.- Measurements of Intracellular Calcium Signals in Polarized Primary Cultures of Normal and Cystic Fibrosis Human Airway Epithelia.- Identification and Quantification of Mucin Expression.- Methods to Classify Bacterial Pathogens in Cystic Fibrosis.- Approaches to Study Differentiation and Repair of Human Airway Epithelial Cells.- Introduction to Part II: Omics in the Biology of Cystic Fibrosis.- Microarray mRNA Expression Profiling to Study Cystic Fibrosis.- Quantitative Differential Proteomics of Cystic Fibrosis Cell Models by SILAC (Stable Isotope Labelling in Cell Culture).- Application of Mass Spectrometry to Study Proteomics and Interactomics in Cystic Fibrosis.- Functional Genomics Assays to Study CFTR Traffic and ENaC Function.- New Lipidomic Approaches in Cystic Fibrosis.- Introduction to Part III: Resources for CFTR Research.- Primary Epithelial Cell Models for Cystic Fibrosis Research.- Comparative Biology of Cystic Fibrosis Animal Models.- CFTR Folding Consortium: Methods Available for Studies of CFTR Folding and Correction.- Evaluation of the Disease Liability of CFTR Variants.
Erscheint lt. Verlag | 11.5.2011 |
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Reihe/Serie | Methods in Molecular Biology ; 742 |
Zusatzinfo | XIV, 384 p. |
Verlagsort | Totowa, NJ |
Sprache | englisch |
Maße | 178 x 254 mm |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Laboratoriumsmedizin |
Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie | |
Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
Schlagworte | CF • genomics • Human clinical trials • Lipidomics • pathophysiology • Proteomics |
ISBN-10 | 1-61779-119-9 / 1617791199 |
ISBN-13 | 978-1-61779-119-2 / 9781617791192 |
Zustand | Neuware |
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