The Quest for the Cure

The Science and Stories Behind the Next Generation of Medicines

Brent Stockwell (Autor)

Buch | Hardcover

284 Seiten

2011
Columbia University Press (Verlag)
978-0-231-15212-9 (ISBN)

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After more than fifty years of blockbuster drug development, skeptics are beginning to fear we are reaching the end of drug discovery to combat major diseases. In this engaging book, Brent R. Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and the powerful techniques that may bring drug research into the twenty-first century. Filled with absorbing stories of breakthroughs, this book begins with the scientific achievements of the twentieth century that led to today's drug innovations. We learn how the invention of mustard gas in World War I led to early anti-cancer agents and how the efforts to decode the human genome might lead to new approaches in drug design. Stockwell then turns to the seemingly incurable diseases we face today, such as Alzheimer's, many cancers, and others with no truly effective medicines, and details the cellular and molecular barriers thwarting scientists equipped with only the tools of traditional pharmaceutical research.
Scientists such as Stockwell are now developing methods to combat these complexities--technologies for constructing and testing millions of drug candidates, sophisticated computational modeling, and entirely new classes of drug molecules--all with an eye toward solving the most profound mysteries of living systems and finding cures for intractable diseases. If successful, these methods will unlock a vast terrain of untapped drug targets that could lead to a bounty of breakthrough medicines. Offering a rare, behind-the-scenes look at this cutting-edge research, The Quest for the Cure tells a thrilling story of science, persistence, and the quest to develop a new generation of cures.

Brent R. Stockwell is an associate professor of biological sciences and chemistry at Columbia University and a Howard Hughes Medical Institute Early Career Scientist. He serves on the editorial board of Chemistry & Biology, has been awarded ten U.S. patents, and has published fifty-four scientific papers. Among his recent honors are a Burroughs Wellcome Fund Career Award at the Scientific Interface and a Beckman Young Investigator Award.

List of Illustrations Preface Acknowledgments Abbreviations Part I. The Vanishing Cures 1. The Drug Discovery Crisis 2. A New Science of Molecules 3. The Birth of the First Cancer Drugs 4. A New Company Creating Drug Combinations 5. The Undruggable RAS Protein 6. The Druggable Genome Part II. The Path to the Next Generation of Medicines 7. Peering Inside Proteins 8. The Nature of Interactions Between Proteins 9. From Protein-Protein Interactions to Personalized Medicines 10. A Revolution in Peptide Synthesis 11. A Vast Array of Drug Candidates 12. Moving Outside the Small Molecule Box 13. Accelerating the Arrival of Next-Generation Drugs Notes Glossary Index

Erscheint lt. Verlag	1.6.2011
Zusatzinfo	4 color illus., 18 line drawings
Verlagsort	New York
Sprache	englisch
Maße	140 x 210 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	0-231-15212-4 / 0231152124
ISBN-13	978-0-231-15212-9 / 9780231152129
Zustand	Neuware