Computational Systems Biology of Cancer

Emmanuel Barillot, Laurence Calzone, Philippe Hupe, Jean-Philippe Vert, Andrei Zinovyev (Autoren)

Buch | Hardcover

492 Seiten

2012
Crc Press Inc (Verlag)
978-1-4398-3144-1 (ISBN)

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The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models—integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools.

Novel Approaches to Fighting CancerDrawn from the authors’ decade-long work in the cancer computational systems biology laboratory at Institut Curie (Paris, France), Computational Systems Biology of Cancer explains how to apply computational systems biology approaches to cancer research. The authors provide proven techniques and tools for cancer bioinformatics and systems biology research.

Effectively Use Algorithmic Methods and Bioinformatics Tools in Real Biological ApplicationsSuitable for readers in both the computational and life sciences, this self-contained guide assumes very limited background in biology, mathematics, and computer science. It explores how computational systems biology can help fight cancer in three essential aspects:

Categorising tumours
Finding new targets
Designing improved and tailored therapeutic strategies

Each chapter introduces a problem, presents applicable concepts and state-of-the-art methods, describes existing tools, illustrates applications using real cases, lists publically available data and software, and includes references to further reading. Some chapters also contain exercises. Figures from the text and scripts/data for reproducing a breast cancer data analysis are available at www.cancer-systems-biology.net.

Emmanuel Barillot, Laurence Calzone, Philippe Hupe, Jean-Philippe Vert, and Andrei Zinovyev are all with the Institut Curie in Paris, France.

Introduction: Why Systems Biology of Cancer? Basic Principles of the Molecular Biology of Cancer. Experimental High-Throughput Technologies for Cancer Research. Bioinformatics Tools and Standards for Systems Biology. Exploring the Diversity of Cancers. Prognosis and Prediction: Towards Individualised Treatments. Mathematical Modelling Applied to Cancer Cell Biology. Mathematical Modelling of Cancer Hallmarks. Cancer Robustness: Facts and Hypotheses. Cancer Robustness: Mathematical Foundations. Finding New Cancer Targets. Conclusion. Appendices. Glossary. Bibliography. Index.

Erscheint lt. Verlag	28.9.2012
Reihe/Serie	Chapman & Hall/CRC Computational Biology Series
Zusatzinfo	6 Tables, black and white; 25 Illustrations, color; 87 Illustrations, black and white
Verlagsort	Bosa Roca
Sprache	englisch
Maße	156 x 234 mm
Gewicht	771 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Naturwissenschaften ► Biologie
	Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
	Technik ► Umwelttechnik / Biotechnologie
ISBN-10	1-4398-3144-0 / 1439831440
ISBN-13	978-1-4398-3144-1 / 9781439831441
Zustand	Neuware