Cancer Precursors

Epidemiology, Detection, and Prevention

Eduardo L. Franco, Thomas E. Rohan (Herausgeber)

Buch | Softcover

430 Seiten

2011 | Softcover reprint of the original 1st ed. 2002
Springer-Verlag New York Inc.
978-1-4419-2901-3 (ISBN)

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Dramatic advances in our understanding of cancer causation have come from epidemiologic and laboratory research, particularly over the past two decades. These developments have included a broadening interest in the critical events that take place during the early stages of the dynamic multistep process leading to - vasive cancer. Increasingly, cancer epidemiologists are pursuing research into the origins and natural history of premalignant lesions, including intermediate or surrogate endpoints, a trend - celerated by the development of molecular technologies that are revolutionizing our understanding of the transformation of normal to malignant cells. There seems little doubt that this emerging knowledge will provide further insights not only into carcinogenic processes, but also into more sensitive methods of early detection and more effective means of prevention. In this book, Drs. Franco and Rohan have succeeded in prep- ing a comprehensive, timely, and critical review of the substantial progress that has been made in our understanding of cancer p- cursors. They have enlisted experts in the ?eld who have c- tributed authoritative chapters on the precursors to a wide variety of cancers,with emphasis on etiology and natural history,including the role of environmental and heritable factors that provoke normal cells to undergo malignant transformation. Epidemiologic data are linked whenever possible to molecular as well as classical cellular pathology, providing a fuller understanding of the causal events and mechanisms that initiate the carcinogenic process.

Site-Specific Precancerous Conditions.- Biological Basis of Carcinogenesis.- Mechanisms and Biological Markers of Carcinogenesis.- Morphology of Cancer Precursor Lesions.- Issues Related to Measurement and Interpretation of Cancer Precursors.- Collection, Processing, and Analysis of Preneoplastic Specimens.- Intermediate Markers in Cancer Research: Theoretical and Practical Issues in the Use of Surrogate Endpoints.- Assessing Epidemiological Relations and the Role of Measurement Errors.- Site-Specific Precancerous Conditions.- Upper Aerodigestive Tract.- Esophagus.- Stomach.- Colon and Rectum.- Anus.- Liver.- Pancreas.- Lung.- Skin.- Breast.- Cervix.- Endometrium.- Ovary.- Vulva and Vagina.- Prostate.- Bladder.- Control of Cancer Precursors.- Screening.- Chemoprevention.- Evidence-Based Policy Recommendations on Screening and Prevention.- Conclusion.- Prospects.

Vorwort	J.F. Fraumeni
Zusatzinfo	XX, 430 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie
	Studium ► Querschnittsbereiche ► Prävention / Gesundheitsförderung
ISBN-10	1-4419-2901-0 / 1441929010
ISBN-13	978-1-4419-2901-3 / 9781441929013
Zustand	Neuware