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Secretion and Action of Gonadotropins

Physiology and Clinic

B. Runnebaum, T. Rabe, L. Kiesel, W. E. Merz (Herausgeber)

Buch | Softcover

V, 96 Seiten

1984
Springer Berlin (Verlag)
978-3-540-13854-9 (ISBN)

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In 1920, Hirose demonstrated the luteinising effect of placental tissue and one year later, Evans and Long described luteinised ovaries in rats treated with hypophysial extracts. In 1926, Zondek and Aschheim as well as Smith, independently of each other, showed that a gonad-stimulating hormone was secreted by the adenohypophysis. In 1927, Aschheim and Zondek found their "Prolan" in human pregnancy urine and the first reliable pregnancy test was available. In the following years it could be demonstrated that the gonadotropic hormones from pituitary and from pregnancy urin were not of identical structure. During the years 1931 - 1933 Fevold and coworkers prepared follicle stimulating hormone from sheep pituitaries which were free of other hormone activities. Already in 1934, Collip found "antihormones" in animals treated with proteinhormones from animals of another species. It could be shown that they were antibodies against these hormones and this was the future basis for the immunological era starting in 1960. The quantitative determination of gonadotropins has been performed over several decades by difficult bioassays and since 1960 immunological and later radioimmunological assays became available. Since that time a new field was opened for the studies of gonadotropins. During this time, highly purified preparations of gonadotropins were available for research and clinical treatment. I recall the first successful attempt of inducing follicle growth and ovulation by Gemzell and coworkers 1958 as well as by Lunenfeld and Bettendorf at about the same time.

Receptors and Actions of Gonadotropin Releasing Hormone (GnRH) in the Anterior Pituitary Gland.- Perpetual Feedback Effect in the Neurons of the Arcuate Nucleus Due to Gonadal Atrophy.- Contraceptive Action of LHRH and Analogues in Animals and in Humans.- Pulsatile Administration of Gn-RH in Hypothalamic Amenorrhea.- Antigonadal Properties of LHRH Agonists: Therapeutical Applications in Human.- Structure-Function Relationships of Gonadotropins: Human Choriogonadotropin as a Model.- Phospholipid Turnover as a Mode of Gonadotropin Releasing Hormone Action in the Ovary.

Erscheint lt. Verlag	1.12.1984
Zusatzinfo	V, 96 p.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	187 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Gynäkologie / Geburtshilfe
	Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
Schlagworte	Gonadotropin
ISBN-10	3-540-13854-4 / 3540138544
ISBN-13	978-3-540-13854-9 / 9783540138549
Zustand	Neuware