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Tissue Repair, Contraction and the Myofibroblast -

Tissue Repair, Contraction and the Myofibroblast

Buch | Softcover
142 Seiten
2011 | Softcover reprint of hardcover 1st ed. 2006
Springer-Verlag New York Inc.
978-1-4419-4145-9 (ISBN)
CHF 224,65 inkl. MwSt
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hirty-four years after the first description of the myofibroblast, the number of publications concerning this cell is very impressive and Tcontinuously expanding, and the work on the myofibroblast involves many laboratories throughout the world. The myofibroblast has been implicated in developmental and physiological phenomena, as well as in a variety of pathological situations, going from wound healing and fibrotic changes to asthma and cancer invasion. Many aspects of myofibroblast biology have been clarified, such as the role of TGF-P and ED-A cellular fibronectin in its differentiation and the role of a-smooth muscle actin in tension production by this cell; however several important problems concerning myofibroblast origin, ftmction and participation in pathological processes remain to be solved. The purpose of this book, as well of the Meeting "Tissue Repair, Contraction and the Myofibroblast" that took place in Nyon, near Geneva, Switzerland on November 18-20, 2004, is to put together the most recent advances in the understanding of myofibroblast biology and to present the main directions of research taking place worldwide to explore new aspects of myofibroblast physiological and pathological activities, such as: mechanisms of force generation by the myofibroblast; myofibroblast origin and diversity; interaction of the myofibroblast with other cells, normal and malignant epithelial cells in particular; and participation of the myofibroblast in the development of fibrosis in various organs. If we consider the animated and constructive discussions that took place during the Nyon Meeting, we are sure that this book will inspire new research in these fields.

Cytomechanics in Connective Tissue Repair and Engineering.- Scleroderma Lung Fibroblasts.- Functional Assessment of Fibroblast Heterogeneity by the Cell-Surface Glycoprotein Thy-1.- Tissue Repair in Asthma.- Experimental Models to Study the Origin and Role of Myofibroblasts in Renal Fibrosis.- Epithelial to Mesenchymal Transition of Mesothelial Cells as a Mechanism Responsible for Peritoneal Membrane Failure in Peritoneal Dialysis Patients.- FIZZy Alveolar Epithelial Cells Induce Myofibroblast Differentiation.- Pro-Invasive Molecular Cross-Signaling between Cancer Cells and Myofibroblasts.- Proangiogenic Implications of Hepatic Stellate Cell Transdifferentiation into Myofibroblasts Induced by Tumor Microenvironment.- Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinase and Matrix Turnover and the Fate of Hepatic Stellate Cells.- Innate Immune Regulation of Lung Injury and Repair.- An Eye on Repair.

Reihe/Serie Biotechnology Intelligence Unit
Zusatzinfo 13 Illustrations, color; 47 Illustrations, black and white; XII, 142 p. 60 illus., 13 illus. in color.
Verlagsort New York, NY
Sprache englisch
Maße 165 x 248 mm
Themenwelt Medizinische Fachgebiete Chirurgie Ästhetische und Plastische Chirurgie
Medizinische Fachgebiete Innere Medizin Pneumologie
Medizinische Fachgebiete Innere Medizin Rheumatologie
Studium 2. Studienabschnitt (Klinik) Pathologie
Naturwissenschaften Biologie Mikrobiologie / Immunologie
Naturwissenschaften Biologie Zellbiologie
ISBN-10 1-4419-4145-2 / 1441941452
ISBN-13 978-1-4419-4145-9 / 9781441941459
Zustand Neuware
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