Proteases in Gastrointestinal Tissues

Uwe Lendeckel, Nigel M. Hooper (Herausgeber)

Buch | Softcover

344 Seiten

2010 | Softcover reprint of hardcover 1st ed. 2006
Springer (Verlag)
978-90-481-7134-7 (ISBN)

Artikel merken

This, the fifth volume in the Proteases in Biology and Disease series, is devoted to Proteases in Gastrointestinal Tissues. Dysregulation of protease expression and/or enzymatic activity is often associated with the onset or progression of disease and, thus, proteases represent interesting targets for the pharmacological therapy of e.

This, the fifth volume in the Proteases in Biology and Disease series, is devoted to Proteases in Gastrointestinal Tissues. Of course, proteases play an important role in the digestion and utilization of ingested proteins, but besides that they elicit a wide range of physiological and pathological effects. Proteases have been recognized as essential regulators, acting both locally and systemically, of normal development, growth and functioning. Dysregulation of protease expression and/or enzymatic activity is often associated with the onset or progression of disease and, thus, proteases represent interesting targets for the pharmacological therapy of e. g. cancer, chronic inflammation, graft rejection, fibrosis, diabetes, vascular disease, and viral or bacterial infections. In addition, changes in the localization, abundance or activity of proteases may serve as informative diagnostic or prognostic markers. This volume focuses on stomach, gut, pancreas, and liver and highlights the role of proteases in normal physiology and disease processes involving these tissues. The first chapter by Nigel W. Bunnett and Graeme S. Cottrell reviews the current knowledge about the protease-activated receptors (PARs) in gastrointestinal tissues. Starting with the mechanisms of activation, signal transduction, and regulation of PAR, their role in controlling gastrointestinal functions and the possible involvement in gastrointestinal diseases are summarized. In Chapter 2, Nikhil I. Khushalani and Nithya Ramnath review the role of matrix metalloproteases (MMPs) and their natural inhibitors, TIMPs, in different types of gastric cancer.

Protease-Activated Receptors in Gastrointestinal Function and Disease.- Matrix Metalloproteinases in Gastric Cancer.- Proteases in Helicobacter pylori-Mediated Diseases.- Proteases in Pancreatic Disease.- PAR in the Pathogenesis of Pain in Pancreatic Disease.- Importance of the Local Renin-Angiotensin System in Pancreatic Disease.- Hepatitis C Viral Proteases And Inhibitors.- Angiotensin Converting Enzyme in the Pathophysiology of Liver Fibrosis.- Matrix Metalloproteinases in Chronic Liver Disease and Liver Transplantation.- MMPs and ADAMs in Inflammatory Bowel Disease.- Chemokines and Matrix Metalloproteinases in Colorectal Cancer.- Angiotensin-Converting Enzyme (ACE) in Gut Inflammation.- Intestinal Apical Protein Transport in Health and Disease.

Erscheint lt. Verlag	16.11.2010
Reihe/Serie	Proteases in Biology and Disease ; 5
Zusatzinfo	XVIII, 344 p.
Verlagsort	Dordrecht
Sprache	englisch
Maße	160 x 240 mm
Themenwelt	Medizinische Fachgebiete ► Chirurgie ► Viszeralchirurgie
	Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie
	Medizinische Fachgebiete ► Innere Medizin ► Hepatologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
ISBN-10	90-481-7134-2 / 9048171342
ISBN-13	978-90-481-7134-7 / 9789048171347
Zustand	Neuware