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Bone Metastasis and Molecular Mechanisms -

Bone Metastasis and Molecular Mechanisms

Pathophysiology

Gurmit Singh, William Orr (Herausgeber)

Buch | Softcover
308 Seiten
2010 | Softcover reprint of hardcover 1st ed. 2004
Springer (Verlag)
978-90-481-6563-6 (ISBN)
CHF 224,65 inkl. MwSt
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Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and prostate cancer.


Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies.

1 Models of Breast Cancer Metastasis to Bone: Characterization of a Clinically Relevant Model.- 2 Quantitation of Bone Metastasis in Experimental Systems.- 3 Comparative Morphometric Study on Bone Remodeling in Human Specimens and in Experimental Models of Metastatic Bone Disease.- 4 Clinical Modalities for the Diagnosis, Characterization and Detection of Bone Metastases.- 5 Metastasis in the Bone Marrow Microenviroment.- 6 The Role of Tumor-Associated Macrophages in Metastasis-Associated Osteolysis.- 7 The Malignant Hierarchy in Multiple Myeloma: Relationships between Malignant Cells and Bone Disease.- 8 Angiogenesis and Lymphangiogenesis in Metastatic Bone Disease: A Matter of Networking.- 9 Prostate Cancer: Models for Developing Novel Therapeutic Approaches.- 10 Potential Therapeutic Targets for Bone Metastasis.- 11 OPG, RANK and RANKL in Bone Metastasis and Cancer-Associated Osteolysis.- 12 Role of Matrix Metalloproteinases in Bone Metastasis from Human Breast and Prostate Cancer.- 13 The Role of Bisphosphonates in Bone Metastasis.

Erscheint lt. Verlag 6.12.2010
Reihe/Serie Cancer Metastasis - Biology and Treatment ; 6
Zusatzinfo XVI, 308 p.
Verlagsort Dordrecht
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Studium 2. Studienabschnitt (Klinik) Pathologie
ISBN-10 90-481-6563-6 / 9048165636
ISBN-13 978-90-481-6563-6 / 9789048165636
Zustand Neuware
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