Cell Immortalization

Buch | Softcover

VII, 208 Seiten

2010 | 1. Softcover reprint of hardcover 1st ed. 2000
Springer Berlin (Verlag)
978-3-642-08491-1 (ISBN)

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The problem of the long-term proliferation of cells is a seminal one. It has always been a hot subject in biology, a source of far-reaching hypotheses, even more so now when explanations for the mechanisms of cell prolifera tive mortality or immortality seem within our reach. A question which is still debated is whether an infinite division potential can be a normal trait or is always the result of modifications leading to abnormal cell growth and escape from homeostasis. In general, investigators have been advocates of one of the two extremes, universal limited or unlim ited normal proliferative potential. Since the long-term proliferative potential of cells concerns regulation of development, regeneration of tissues, and homeostatic control of cell growth, in brief survival of living organisms, and since the regulation of these processes is so different along the evolutionary scale, it is not surpris ing that there does not seem to be any universal trait. The question of whether cells are endowed with finite or infinite prolifera tive phenotypes has to be seen using the perspective of comparative biology.

A Theory on Cellular Aging and Cell Immortalization.- Cell Immortality: Maintenance of Cell Division Potential.- Comparative Biology of Cell Immortalization.- Clonal Life Cycle of Paramecium in the Context of Evolutionary Acquired Mortality.- Cellular Genealogy of In-Vitro Senescence and Immortalization.- SV40-Mediated Immortalization.- Concepts of Immortalization in Human Mammary Epithelial Cells.- Telomeres and Cell Division Potential.- Cellular mortality and Immortalization: A Complex Interplay of Multiple Gene Functions.

Erscheint lt. Verlag	4.12.2010
Reihe/Serie	Progress in Molecular and Subcellular Biology
Zusatzinfo	VII, 208 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	334 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	aging • Biology • Cancer • Cell • cell division • Cell immortalization • Evolution • Gene • Krebs • Mortality • senescence • Seneszenz
ISBN-10	3-642-08491-5 / 3642084915
ISBN-13	978-3-642-08491-1 / 9783642084911
Zustand	Neuware