On Angiotensin-Degrading Aminopeptidases in the Rat Kidney

P. Kugler (Autor)

Buch | Softcover

VIII, 88 Seiten

1982
Springer Berlin (Verlag)
978-3-540-11452-9 (ISBN)

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The octapeptide angiotensin II (ANG II, Fig. 1) is the key effector substance of the renin-angiotensin system (RAS) (Werning 1972, Page and Bumpus 1974, Hierholzer 1977, Vecsei et al. 1978, Johnson and Anderson 1980 lit. ). ANG II is formed in two enzymatic steps. Renin acts on renin substrate, a glycoprotein, to produce angiotensin I (ANG I, a decapeptide), which in turn is acted upon by converting enzyme to form ANG II (Skeggs et al. 1968, Fig. 1). Renin substrate (angiotensinogen) is produced mainly in the liver (Page et al. 1941) and is a constituent of the ~-globulin fraction in the circulating plasma (Plentl et al. 1943). The two enzymes involved in the formation of ANG II from renin substra te are formed at various sites in the body. Renin (E. C. 3. 4. 99. 19) is produced mainly in the granular epithelioid cells of the kidney (Cook 1971, Taugner et al. 1979, Davi doff and Schiebler 1981), and converting enzyme (CE, E. C. 3. 4. 15. 1) occurs chiefly in the lung (Ng and Vane 1967, Bakhle 1974 lit. ) as well as in numerous other tissues, such as the juxtaglomerular apparatus of the kidney (Granger et al. 1969, 1972) and the brush border of the renal proximal tubule (Ward et al. 1975, 1976; Ward und Erdos 1977). The biological effects of ANG II are numerous.

1 Introduction.- 2 Materials and Methods.- 2.1 Material.- 2.2 Qualitative Histochemistry.- 2.3 Quantitative Enzyme Histochemistry of Aminopeptidase A.- 2.4 Biochemistry of APA and APM.- 2.5 Methods of Investigating Kidneys from Experimental Animals.- 2.6 Chemicals and Suppliers.- 2.7 Abbreviations.- 3 Results.- 3.1 Methodological Studies.- 3.2 Histochemical Localization of APA and APM in the Normal Kidney.- 3.3 Animal Experiments.- 4 Discussion.- 4.1 Methodological Aspects.- 4.2 Animal Experiments.- 4.3 Conclusion.- 5 Summary.- References.

Erscheint lt. Verlag	1.6.1982
Reihe/Serie	Advances in Anatomy, Embryology and Cell Biology
Übersetzer	T. Telger
Zusatzinfo	VIII, 88 p. 19 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	205 g
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Anatomie / Neuroanatomie
Schlagworte	Aminopeptidase • Angiotensin • biochemistry • Enzyme • glycoprotein • kidney • Lung • Microscopy • Niere • Rat • tissue
ISBN-10	3-540-11452-1 / 3540114521
ISBN-13	978-3-540-11452-9 / 9783540114529
Zustand	Neuware