Inflammation and Demyelination in the Central Nervous System

International Congress of Neuropathology, Vienna, September 5–10, 1982

B. H. Waksman, T. Yonezawa, H. Lassmann (Herausgeber)

Buch | Softcover

VI, 94 Seiten

1983
Springer Berlin (Verlag)
978-3-540-12420-7 (ISBN)

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The present report, compares two murine models of virus induced chronic relapsing demyelination. MHV-induced demyelination in the BALB/c mouse results from the direct virus mediated cytolysis of oligodendrocytes. Extensive remyelination by oligodendrocytes is noted. Recurrent demyel ination occurs in small areas. Infectious virus persists and 34 Fig. 2: Demyelination in SJL/J mice infected with TMEV. A) Multifocal areas of perivascular demyelination in the spinal cord (110 days post infection). Para phenylene diamine stain. X 250. B) Perivascular inflammatory infiltration within the white matter of the spinal cord (22 days post infec tion). Paraphenylene diamine stain. X600. C) Localization of TMEV associated antigen in the cytoplasm of oligodendrocytes (45 days post infec tion). Vibratome section stained with the peroxidase-anti peroxidase technique. X 400. D) Immunoperoxidase staining of viral antigen within inner and outer loops of an oligodendrocyte (45 days post infectin) X 60,000. E) Longitudinal section showing viral antigen within Schmidt-Lanterman incisures (80 days post infection). X 49,000. viral antigens are localized within oligodendrocytes and their processes. TMEV-induced demyelination in SJL/J mice is asso ciated with perivascular inflammatory infilrates and is dimin ished by immunosuppressive measures. Remyelination by oligo dendrocytes is delayed and incomplete. Chronic demyelination is widespread and associated with perivascular inflammatory infiltrates. The virus persists and viral antigen is local ized within oligodendrocytes.

Immunologic Models of Acute and Chronic Inflammation.- Abnormalities of Immunocyte Function in Multiple Sclerosis.- Etiology and Pathogenesis of Monophasic and Relapsing Inflammatory Demyelination - Human and Experimental.- Virologic Models of Chronic Relapsing Demyelinating Disease.- Murine Experimental Allergic Encephalomyelitis.- Circulating Myelinotoxic Factors in Human and Experimental Demyelinative Disease.- Analysis of Humoral and Cellular Events and the Role of Lipid Haptens During CNS Demyelination.- Neurochemical and Model Membrane Studies in Demyelinating Diseases.

Erscheint lt. Verlag	1.8.1983
Reihe/Serie	Acta Neuropathologica Supplementa
Zusatzinfo	VI, 94 p. 8 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	210 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Schlagworte	Antigen • Entmarkungskrankheit • Entzündung • Infection • Infectious • Infectious Diseases • inflammation • System • Virus • Zentralnervensystem /Erkrankung
ISBN-10	3-540-12420-9 / 3540124209
ISBN-13	978-3-540-12420-7 / 9783540124207
Zustand	Neuware