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Hepatitis Delta Virus -

Hepatitis Delta Virus

John L. Casey (Herausgeber)

Buch | Softcover
XII, 228 Seiten
2010 | 1. Softcover reprint of hardcover 1st ed. 2006
Springer Berlin (Verlag)
978-3-642-06751-8 (ISBN)
CHF 224,65 inkl. MwSt
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Hepatitis delta virus which causes severe acute and chronic liver disease was discovered following the detection of a novel antigen-antibody system in hepatitis B virus carriers. Currently, HDV is classified as a subviral satellite of hepatitis B virus. However, unlike other satellite viruses, the dependence of HDV on HBV is limited solely to the provision of an envelope of hepatitis B surface antigen for virus assembly. Research into the molecular virology of the HDV life cycle has revealed a fascinating collection of biology. These insights are now beginning to be translated into new potential treatment strategies. There are currently still an estimated 15 million HDV carriers worldwide.

Structure and Replication of Hepatitis Delta Virus RNA.- HDV RNA Replication: Ancient Relic or Primer?.- HDV Ribozymes.- RNA Editing in Hepatitis Delta Virus.- Post-translational Modification of Delta Antigen of Hepatitis D Virus.- The Role of the HBV Envelope Proteins in the HDV Replication Cycle.- Prenylation of HDAg and Antiviral Drug Development.- Hepatitis Delta Virus Genetic Variability: From Genotypes I, II, III to Eight Major Clades?.- Functional and Clinical Significance of Hepatitis D Virus Genotype II Infection.- Immunology of HDV Infection.- The Woodchuck Model of HDV Infection.

Erscheint lt. Verlag 12.2.2010
Reihe/Serie Current Topics in Microbiology and Immunology
Zusatzinfo XII, 228 p. 18 illus., 1 illus. in color.
Verlagsort Berlin
Sprache englisch
Maße 155 x 235 mm
Gewicht 369 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Mikrobiologie / Infektologie / Reisemedizin
Naturwissenschaften Biologie Mikrobiologie / Immunologie
Schlagworte Antibody • Antigen • antigenomic RNA • cytotoxic T-cell • delta protein • Genetics • genetic variability • HBV envelope proteins • Hepatitis • Hepatitis B • hepatitis delta antigen • immunology • Infection • Liver • liver disease • Posttranslational modification • prenylation • Protein • proteins • Ribozyme • RNA • RNA editing • RNA polymerase • RNA replication • Virology • Virus • woodchuck model
ISBN-10 3-642-06751-4 / 3642067514
ISBN-13 978-3-642-06751-8 / 9783642067518
Zustand Neuware
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