Control of Biofilm Infections by Signal Manipulation

Buch | Softcover

XVI, 175 Seiten

2010 | 1. Softcover reprint of hardcover 1st ed. 2008
Springer Berlin (Verlag)
978-3-642-09309-8 (ISBN)

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In the well-watered groves of academe, most of us are content to gather worshipful students and technicians in a shady nook to contemplate the eternal verities and to plan extravagant feasts to celebrate our contributions to "knowledge" and to the gradual improvement of the human condition. As one convocation follows another, and as our funding agencies pump billions of dollars into incremental research that ?lls every possible pigeon-hole in which a gene makes a protein, a small number of intellectual athletes seize a pivotal concept and plunge into the real world. It is this small band of nimble and impossibly brave intellectual halfbackswho win gamesin the real world, and this book is the result of the drive and intellectual athleticism of its editor and several of her contributors. Bacteria affect humans more than any other life forms with which we share the blue planet, but our understandingof these invisible companionshas developed in a staggering pattern, crippled by our panic and consequent shifts of emphasis. When our race was threatened by epidemic diseases, we visualized bacteria as swarms of potentially lethal planktoniccells from which we must remain isolated by sanitation and which we had to kill by immunization and chemical antibacterial compounds. By the time this overriding threat had been obviated, we began to examine na- ral and pathogenic ecosystems by direct methods, and we were surprised to ?nd that planktonic bacteria are comparatively rare and that most prokaryotes grow in matrix-enclosedbio?lms.

Bacterial Cell-to-cell Communication (Quorum Sensing).- Detection In Vitro of Quorum-Sensing Molecules and Their Inhibitors.- Quorum-Sensing Inhibitory Compounds.- Mathematical Modeling of Quorum-Sensing Control in Biofilms.- Animal Models Commonly Used to Study Quorum-Sensing Inhibitors.- In Vivo Studies: Inhibiting Biofilm-Associated Bacterial Infections Using QSIs.- Quorum Sensing in Streptococci.- Ironing Out the Biofilm Problem:The Role of Iron in Biofilm Formation.- Clinical Wound Healing Using Signal Inhibitors.

Erscheint lt. Verlag	20.11.2010
Reihe/Serie	Springer Series on Biofilms
Vorwort	J.W. Costerton
Zusatzinfo	XVI, 175 p. 56 illus., 13 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	299 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	Antibiotics • Bacteremia • Bacteria • bacterial infection • Bacterial Infections • Biofilm • biofilm infection • Infection • Infections • Infectious Diseases • Molecular mechanisms • Plankton • Proteomics • signal manipulation
ISBN-10	3-642-09309-4 / 3642093094
ISBN-13	978-3-642-09309-8 / 9783642093098
Zustand	Neuware