Introduction to Drug Metabolism

G. Gordon Gibson, Paul Skett (Autoren)

Buch | Softcover

293 Seiten

1986 | Softcover reprint of the original 1st ed. 1986
Chapman and Hall (Verlag)
978-0-412-26390-3 (ISBN)

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Although the scientific literature on drug metabolism is extensive, it suffers from the disadvantage that the material is diffuse and consists largely of specialist monographs dealing with particular aspects of the subject. In addi tion, although there are a few excellent texts on drug metabolism in print, these tend to be earlier publications and hence do not take into account the many recent advances in this area. Our motivations for writing this book therefore arose from the clear need for a recent and cohesive introductory text on this subject, specifically designed to cater for the needs of undergraduate and postgraduate students. Much of the subject matter in this text is derived from various courses on drug metabolism given at the University of Surrey and the University of Glasgow to basic science students in pharmacology, biochemistry, nutrition and nursing studies, to pre-clinical medical students and to under graduate and post-graduate students in toxicology. Therefore, it is our inten tion that this text will serve as a primer in drug metabolism to a variety of students in the life sciences taking courses in this subject. The term 'drug metabolism' in its broadest sense may be considered as the absorption, distribution, biotransformation and excretion of drugs. To cover all these facets of drug metabolism in a single text is a voluminous task and therefore we have focused primarily on the biotransformation aspects of the subject.

1 Pathways of drug metabolism.- 2 Enzymology and molecular mechanisms of drug metabolism.- 3 Induction and inhibition of drug metabolism.- 4 Factors affecting drug metabolism: internal factors.- 5 Factors affecting drug metabolism: external factors.- 6 Pharmacological and topological aspects of drug metabolism.- 7 Pharmacokinetics and the clinical relevance of drug metabolism.- 8 Techniques and experiments illustrating drug metabolism.

Erscheint lt. Verlag	1.1.1986
Zusatzinfo	XII, 293 p.
Verlagsort	London
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Themenwelt	Medizin / Pharmazie ► Pharmazie
ISBN-10	0-412-26390-4 / 0412263904
ISBN-13	978-0-412-26390-3 / 9780412263903
Zustand	Neuware