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Urinary Tract

Karl-Erik Andersson, Martin C. Michel (Herausgeber)

Buch | Hardcover

XII, 580 Seiten

2011 | 2011
Springer Berlin (Verlag)
978-3-642-16498-9 (ISBN)

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Internationally leading experts have summarized and analyzed the latest data with regard to the anatomy, physiology and pharmacology of the urinary tract. The basic anatomy and physiology of the urinary tract, the validity of animal models and other methodological considerations as well as a range of potential therapeutic targets are comprehensively reviewed by leading international experts, making this a unique reference source for basic scientists and research-minded clinicians alike

Preface.- Overview on the lower urinary tract. Animal models in overactive bladder research. Animal models of stress urinary incontinence. Animal models for benign prostatic hyperplasia. Use of functional imaging to monitor central control of voiding in humans. Neuroanatomy of the lower urinary tract. Anatomy and histology of the lower urinary tract. Neurophysiology of the lower urinary tract. Afferent mechanism in the urinary tract. Urothelial signaling. Interstitial cells of Cajal in the urinary tract. Potential Applications of gene therapy/transfer to the treatment of lower urinary tract diseases/disorders. Specific pharmacokinetic aspects of the urinary tract. ₁-Adrenoceptors in the urinary tract. beta-Adrenergic receptor subtypes in the urinary tract. Muscarinic acetylcholine receptors in the urinary tract. Modulation of urinary bladder innervation: TRPV1 and botulinum toxin A. Ion channel modulators and urinary tract function. Neuropeptides in lower urinary tract function. Cannabinoid: potential targets for the treatment of bladder dysfunction. Vasopressin receptors in voiding dysfunction. ATP & P2X purinoceptors in urinary tract disorders. Cyclic nucleotide metabolism including nitric oxide and phosphodiesterase-related targets in the lower urinary tract. Rho kinase a common final pathway of various contractile bladder and ureter stimuli.

Erscheint lt. Verlag	24.2.2011
Reihe/Serie	Handbook of Experimental Pharmacology
Zusatzinfo	XII, 580 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	951 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Themenwelt	Medizin / Pharmazie ► Pharmazie
Schlagworte	bladder • Prostate • Ureter • Urethra
ISBN-10	3-642-16498-6 / 3642164986
ISBN-13	978-3-642-16498-9 / 9783642164989
Zustand	Neuware