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Ichthyoses

Clinical, Biochemical, Pathogenic and Diagnostic Assessment.

P.M. Elias, M.L. Williams, D. Crumrine, M. Schmuth (Autoren)

Buch | Hardcover

144 Seiten

2010
Karger, S (Verlag)
978-3-8055-9394-6 (ISBN)

Lese- und Medienproben

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The various manifestations of ichthyoses are classified either by their appearance or their molecular genetics. This volume focuses on generalized, inherited disorders of cornification, which constitute an ever-enlarging group of monogenic diseases caused by a large number of genes that affect a broad array of cellular functions. The authors' overview reflects their unique perspective that the clinical phenotype in the inherited ichthyoses mirrors a 'best attempt' by a metabolically compromised epidermis to maintain a barrier sufficiently impermeable for survival in a desiccating external environment. The basis for threats to survival is illuminated, and the systemic problems, including growth failure, also reflect a compromised barrier. A new consensus classification of these disorders is provided, and the distinguishing clinical features of each disorder are described. Further, the latest molecular genetic information is succinctly reviewed with up-to-date and comprehensive references. Yet, the major emphases of this volume are on disease pathogenesis and on the identification of key ultrastructural features. This publication will prove an invaluable aid to dermatologists, pediatric dermatologists and pediatricians dealing with patients with inherited ichthyoses. In addition, clinical geneticists and dermatopathologists will find it interesting reading.

Erscheint lt. Verlag	29.9.2010
Reihe/Serie	Current Problems in Dermatology
Mitarbeit	Herausgeber (Serie): P. Itin, G.B.E. Jemec
Zusatzinfo	89 fig., 15 in color, 9 tab.
Verlagsort	Basel
Sprache	englisch
Gewicht	690 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
Schlagworte	Dermatology • Genetics • Hardcover, Softcover / Medizin/Klinische Fächer • Histology • Ichthyose • Metabolism • Pediatrics
ISBN-10	3-8055-9394-5 / 3805593945
ISBN-13	978-3-8055-9394-6 / 9783805593946
Zustand	Neuware