Research Progress in Alzheimer's Disease & Dementia
Nova Science Publishers Inc (Verlag)
978-1-60876-152-4 (ISBN)
Alzheimer's disease (AD), the most common form of neurodegenerative disorder in the elderly, is characterised pathologically by extracellular amyloid plaques and intracellular neurofibrillary tangles, pathophysiologically by synaptic dysfunction, and clinically by a progressive decline in cognition. Currently, AD has no cure and its prevalence is predicted to triple by 2050 with the rapid increase in the ageing population, unless more effective prevention/treatments are developed. Since the publication of the third book volume, the rapid progress in the research fields of AD and dementia continues through the intensive efforts of research scientists world-wide. This fourth book volume contains 12 chapters, bringing together a presentation of scientific frontiers in current AD/dementia research. The topics include emotional memory in AD, amyloid-B clearance, synaptic transmission-mediated regulation of amyloid-B dynamics, anti-AD immunotherapy, clinical trials of AD therapeutics using AD transgenic mouse models, roles of apolipoprotein E, chronic inflammation, cathepsins, and gelsolin in AD pathogenesis and as anti-AD therapeutic targets/agents, declarative memory impairment and hippocampal atrophy in Parkinson's disease, fronto-temporal dementia, and cognitive impairment in schizophrenia. These chapters cover current advances in our understanding of the pathogenic mechanisms underlying AD and dementia, in the diagnosis of early AD and dementia, and in the development of therapeutic agents that target memory-relevant AD pathogenesis. The book will be highly valuable to students and scientists world-wide who are interested in the scientific research progress in AD and memory disorders.
Miao-Kun Sun, Ph.D. obtained his Ph.D. at the Department of Pharmacology, University of Virginia, in 1986, and continued postdoctoral research at the same department for two more years. After a brief research period (one year) at the Department of Physiology, Royal Free Hospital School of Medicine, University College of London, he accepted a faculty position at Department of Neurology and Neuroscience, Cornell University Medical College in New York in 1990. His current position is Professor at Blanchette Rockefeller Neurosciences Institute (holding the same position since 2000).
Preface; Emotional Memory in Alzheimer's Disease; Mechanisms of Amyloid-B Clearance in Alzeheimer's Disease; Synaptic transmission regulates amyloid-|A dynamics; Anti-AB Antibodies For the Treatment of Alzheimer's Disease; The Failure of the APP Transgenic Mouse Models to Predict Efficacy of Agents in Five Clinical Trials of Alzheimer's Disease Suggests That There is a Need for a New Paradigm for Drug Development.; Apolipoprotein E & Alzheimer's Disease: An Update on Allele-Specific Effects of Disease Etiology; Chronic Inflammation & Alzheimer's Disease; Cathepsins in Alzheimer's disease & dementia: Cathepsin inhibitors as potential anti-dementic therapeutics; Role of gelsolin in Alzheimer's disease; Declarative memory impairment & hippocampal atrophy in Parkinson's disease; Fronto-temporal dementia; Cognitive impairment in schizophrenia; Index.
| Erscheint lt. Verlag | 24.3.2010 |
|---|---|
| Zusatzinfo | Illustrations |
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 260 x 180 mm |
| Gewicht | 768 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Geriatrie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie | |
| ISBN-10 | 1-60876-152-5 / 1608761525 |
| ISBN-13 | 978-1-60876-152-4 / 9781608761524 |
| Zustand | Neuware |
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