Biofilm Eradication and Prevention

A Pharmaceutical Approach to Medical Device Infections

Tamilvanan Shunmugaperumal (Autor)

Buch | Hardcover

438 Seiten

2010
John Wiley & Sons Inc (Verlag)
978-0-470-47996-4 (ISBN)

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Biofilm Eradication and Prevention presents the basics of biofilm formation on medical devices, diseases related to this formation, and approaches pharmaceutical researchers can take to limit this problem. The book first covers the development and characterization of biofilm on the surfaces of implanted or inserted medical devices.

Biofilm Eradication and Preventions presents the basics of biofilm formation on medical devices, diseases related to this formation, and approaches pharmaceutical researchers need to take to limit this problem. Split into three parts, the first deals with the development and characterization of biofilm on the surfaces of implanted or inserted medical devices. Questions as to why biofilms form over medical device surfaces and what triggers biofilm formation are addressed. In the second section, the author discusses biofilm-mediated chronic infections occurred in various organs (eyes, mouth, wounds) and pharmaceutical and drug delivery knowledge gained from research in these area. The third part explores pharmaceutical approaches like lipid-and polymer-based drug delivery carriers for eradicating biofilm on device-related infections. In addition, this section also explores the topic of novel small molecule (like iron and its complexes/metal chelators) and a quorum-sensing inhibitors to control medical biofilm formation.

TAMILVANAN SHUNMUGAPERUMAL, PhD, works in the Department of Pharmaceutical Technology at the International Medical University in Kuala Lumpur, Malaysia. His current research seeks to exploit the potential of lipid- and polymer-based drug delivery carriers to eradicate infectious biofilm formation associated with both medical devices and human organs.

PREFACE. ACKNOWLEDGMENTS.

PART I. DEVELOPMENT AND CHARACTERIZATION OF BIOFILMS.

1. INTRODUCTION AND OVERVIEW OF BIOFILM.

2. RATIONALE FOR BIOFILM ERADICATION FROM MODERN MEDICAL DEVICES.

3. PATHOGENESIS OF DEVICE-RELATED NOSOCOMIAL INFECTIONS.

4. BIOFILM RESISTANCE–TOLERANCE TO CONVENTIONAL ANTIMICROBIAL AGENTS.

5. ANALYTICAL TECHNIQUES USEFUL TO STUDY BIOFILMS.

PART II. BIOFILM-RELATED INFECTIONS IN VARIOUS HUMAN ORGANS (NONDEVICE-RELATED CHRONIC INFECTIONS).

6. BIOFILM-RELATED INFECTIONS IN OPHTHALMOLOGY.

7. BIOFILM-RELATED INFECTIONS IN THE ORAL CAVITY.

8. IMPLICATIONS OF BIOFILM FORMATION IN CHRONIC WOUNDS AND IN CYSTIC FIBROSIS.

PART III. DRUG DELIVERY CARRIERS TO ERADICATE BIOFILM FORMATION ON MEDICAL DEVICES.

9. STRATEGIES FOR PREVENTION OF DEVICE-RELATED NOSOCOMIAL INFECTIONS.

10. LIPOSOMES AS DRUG DELIVERY CARRIERS TO BIOFILMS.

11. POLYMER-BASED ANTIMICROBIAL DELIVERY CARRIERS.

INDEX.

Erscheint lt. Verlag	6.8.2010
Verlagsort	New York
Sprache	englisch
Maße	161 x 243 mm
Gewicht	798 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Naturwissenschaften ► Chemie
	Technik ► Maschinenbau
	Technik ► Medizintechnik
ISBN-10	0-470-47996-5 / 0470479965
ISBN-13	978-0-470-47996-4 / 9780470479964
Zustand	Neuware