Microarray Methods for Drug Discovery
Humana Press Inc. (Verlag)
978-1-60761-662-7 (ISBN)
The postgenomic era presents a multitude of challenges for scientists in all areas of science. The information overload from new discoveries in genomics and proteomics highlight how little we really know about the functioning of a cell. The advent of Next-Generation Sequencing technologies promises to make our genetic blueprint available to the common man. The availability of the plethora of biological information has lead to the devel- ment of new areas of science and the coining of new "omics" terms including transcr- tomics, methylomics, toxicogenomics, pharmacogenomics, metabolomics, lipidomics, and so on. Remarkable research is being conducted to understand the various aspects of human health and how processes like histone modifcations, promoter usage, alternative splicing, posttranscriptional, and posttranslational modifcations contribute to disease. The advent of systems biology has unifed chemists and biochemists alike in the struggle to eradicate or treat human disease. Microarrays have blossomed into a fast developing and cutting-edge technology that promises to become a major component of personalized medicine.
The 1990s witnessed a boom in many areas including genome sequencing, combinatorial chemistry, and c- puters, all of which have contributed to the development of microarray technology from its infancy into a mature tool. The growing potential of this tool is evident from the n- ber of publications since 1991 when Fodor et al. of Affymax (now Affymetrix) frst described the microarray prototype.
Multicenter Clinical Sample Collection for Microarray Analysis.- Isolation of Total RNA from Transgenic Mouse Melanoma Subsets Using Fluorescence-Activated Cell Sorting.- Microarray Analysis of Embryonic Stem Cells and Differentiated Embryoid Bodies.- Determination of Alternate Splicing Events Using the Affymetrix Exon 1.0 ST Arrays.- Profiling microRNA Expression with the Illumina BeadChip Platform.- TaqMan® Array Cards in Pharmaceutical Research.- DMET™ Microarray Technology for Pharmacogenomics-Based Personalized Medicine.- The Use of Microarray Technology for Cytogenetics.- PCR/LDR/Universal Array Platforms for the Diagnosis of Infectious Disease.- RIP-CHIP in Drug Development.- ChIPing Away at Global Transcriptional Regulation.- HELP (HpaII Tiny Fragment Enrichment by Ligation-Mediated PCR) Assay for DNA Methylation Profiling of Primary Normal and Malignant B Lymphocytes.- High-Throughput Screening of Metalloproteases Using Small Molecule Microarrays.- Metabolic Enzyme Microarray Coupled with Miniaturized Cell-Culture Array Technology for High-Throughput Toxicity Screening.- Use of Tissue Microarray to Facilitate Oncology Research.- Small Molecule Selectivity and Specificity Profiling Using Functional Protein Microarrays.- Production and Application of Glycan Microarrays.
| Erscheint lt. Verlag | 18.3.2010 |
|---|---|
| Reihe/Serie | Methods in Molecular Biology ; 632 |
| Zusatzinfo | XI, 285 p. |
| Verlagsort | Totowa, NJ |
| Sprache | englisch |
| Maße | 178 x 254 mm |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| Medizin / Pharmazie ► Pharmazie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| ISBN-10 | 1-60761-662-9 / 1607616629 |
| ISBN-13 | 978-1-60761-662-7 / 9781607616627 |
| Zustand | Neuware |
| Haben Sie eine Frage zum Produkt? |
aus dem Bereich
