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Acute Myelogenous Leukemia

Buch | Softcover

350 Seiten

2009
Springer-Verlag New York Inc.
978-1-4419-1299-2 (ISBN)

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Acute myelogenous leukemia (AML), is the most common form of leukemia in adults. AML is a deadly form of malignancy, the prognosis for which has not improved in the last two decades. More importantly, it is a malignancy that is seen in older adults, therefore the number of cases is likely to rise as the population ages. Over the past 15 years, genetic mechanisms underlying AML have begun to unfold. Additional research in this area has helped identify key components and characteristics. Consequently, targeted therapy of AML is receiving much attention. It is the hope of researchers that as with chronic myelogenous leukemia (CML), and the drug, Gleevec, a targeted therapy for AML will be discovered.

Lalitha Nagarajan is an Associate Professor, Department of Molecular Genetics, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas.

The Leukemia Stem Cell.- Epigenetic Mechanisms in AML - a Target for Therapy.- Chromosomal Translocations in AML: Detection and Prognostic Significance.- Chromosomal Deletions in AML.- Genes Predictive of Outcome and Novel Molecular Classification Schemes in Adult Acute Myeloid Leukemia.- Receptor Tyrosine Kinase Alterations in AML -- Biology and Therapy.- Lineage Specific Transcription Factor Aberrations in AML.- Pro-leukemic RUNX1 and CBFss Mutations in the Pathogenesis of Acute Leukemia.- Acute Myeloid Leukemia with Mutated Nucleophosmin (NPM1): Molecular, Pathological and Clinical Features.- MicroRNAs: New Players in AML Pathogenesis.- Murine Models of Human Acute Myeloid Leukemia.- AML and Apoptosis.- Acute Promyelocytic Leukemia, a Paradigm for Differentitation Therapy.- Immunotherapy of AML.- Therapy of Acute Myelogenous Leukemia in Adults.

Erscheint lt. Verlag	1.10.2009
Reihe/Serie	Cancer Treatment and Research ; v. 145
Zusatzinfo	5 black & white illustrations, 20 colour illustrations
Verlagsort	New York, NY
Sprache	englisch; Multiple languages
Maße	155 x 235 mm
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Hämatologie
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
ISBN-10	1-4419-1299-1 / 1441912991
ISBN-13	978-1-4419-1299-2 / 9781441912992
Zustand	Neuware