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Immune Infertility

The Impact of Immune Reactions on Human Infertility
Buch | Hardcover
XI, 236 Seiten
2009 | 2009
Springer Berlin (Verlag)
978-3-642-01378-2 (ISBN)
CHF 299,55 inkl. MwSt
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This book offers an overview of immune reactions inducing fertility disorders in both sexes. It discusses the nature, the origin and induction of antisperm antibodies and the role of reproductive organs and their interaction with the immune system.
Infertility is defned as the inability to conceive after having unprotected intercourse for a year. Infertility is increasing worldwide and has various causes both in the male and the female partner. Immune reactions to sperm can contribute up to 2-30% of infertility. The sperm has both autoantigenic as well as isoantigenic potential, and is thus capable of p- ducing antisperm antibodies (ASAs) and sperm-reactive T cells in both infertile men and women. Also, over 75% vasectomized men produce autoantibodies to sperm that can cause a problem in regaining fertility even after successful re-anastomosis in vasovasostomy. Early claims regarding the incidence and involvement of ASAs in involuntary human infertility were probably overemphasized because of unreliable techniques and naivety concerning the complexity of the immune response and antigenic nature of the sperm cell. These factors, the lack of well-designed and controlled experimental studies, and the dearth of effective therapeutic modalities resulted in the confusion of the occurrence and importance of ASAs in human infertility. Consequently, evaluation of infertile couples for ASAs and their possible role in infertility was not considered a signifcant proposition. The development of more accurate assays and the discovery of mucosal immunity capable of responses independent of systemic immunity have caused inclusion of sperm cells and genital tract secretions in the analysis of ASAs.

Sperm Antigens.- Proteomics of Human Spermatozoa.- Methods of Analysis of Sperm Antigens Related to Fertility.- Sperm Surface Proteomics.- Sperm Functions Influenced by Immune Reactions.- Antisperm Antibodies (ASA).- The Immune Privilege of the Testis.- Immune Chemistry of ASA.- Sperm-Specific T Lymphocytes.- Site and Risk Factors of Antisperm Antibodies Production in the Male Population.- Biologic Substrates Containing ASA.- ASA in the Female.- Sperm-Immobilizing Antibody and Its Target Antigen (CD52).- The Clinical Impact of Sperm Antibodies.- Male Autoimmune Infertility.- Tests for Sperm Antibodies.- Impact on Fertility Outcome.- Sperm Antibodies and Assisted Reproduction.- Treatment of Immune Infertility.- Immune Contraception.- Immunization with Sperm Antigens to Induce Contraception.- Immunocontraception in Wildlife Animals.- Experience from Clinical Trials with Fertility Control Vaccines.

From the reviews: "The authors direct their work to clinicians, scientists, trainees in reproductive biology, obstetricians/gynecologists, and urologists. ... This highly specialized field is clearly depicted with the aid of graphs, tables, schematic diagrams, and exquisite photomicrographs. ... This is a unique, comprehensive, and cogent update of basic and therapeutic advances in the field of immunoinfertility." (Irvin H. Hirsch, Doody's Review Service, December, 2009)

Zusatzinfo XI, 236 p.
Verlagsort Berlin
Sprache englisch
Maße 155 x 235 mm
Gewicht 544 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete
Schlagworte Antigen • antisperm antibodies (ASA) • assisted reproduction • autoimmune infertility • clinical trial • Contraception • fertility • immune chemistry • immune contraception • immune contraceptives • Infertility • Lymphocytes • Medicine • Reproduction • sperm antibodies • sperm antigens • Spermatozoa • Testis • Treatment • Unfruchtbarkeit • Vaccine
ISBN-10 3-642-01378-3 / 3642013783
ISBN-13 978-3-642-01378-2 / 9783642013782
Zustand Neuware
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