Telomeres
Nova Science Publishers Inc (Verlag)
978-1-60692-350-4 (ISBN)
Telomeres are a region of repetitive DNA at the end of chromosomes, which protects the end of the chromosome from destruction. They protect chromosome ends from degradation and thus prevent chromosome end fusion. This book describes the relevance of telomeres in the human ageing process and the telomere defects that play a role in the premature aging process. Dysfunctional telomeres that can promote chromosome instability, leading to DNA amplifications and terminal deletions-, cell cycle arrest and cell death, are also described. The biology and function of both telomeres and telomerase are described in this book. The possible connection between telomeres, ageing and senescence, as well as the many disorders and chronic diseases where telomere biology seems to be important are addressed, as well as future therapeutic perspectives. The importance of this enzyme in cancer is reviewed in this book. The data of various kind of cancers are discussed, in addition to the clinical application of telomere and telomerase in human cancer. The role of telomere dysfunction in apoptosis and senescence, as well as its role in newly proposed models that link telomere loss to chromosome missegregation in mitosis, are explained. Characteristic differences of telomere lengthening during oocyte and spermatozoa growth(during embryo development) is also reviewed as well as the transcriptional activity at the telomeres of Chironomus (Diptera) and its possible role in the lengthening of the telomeres. Telomere shortening in Diabetes Mellitus is also described, as well as its association with hypertension, diabetes mellitus, insulin resistance, obesity and cardiovascular mortality. The notion that alterations in the three-dimensional organisation of telomeres may cause malignant transformation is also addressed.
Preface; Telomere Dynamics and Biology in Human Progeroid Syndromes; The Role of Telomere-Telomerase System in Age-Related Fitness Decline, A Tameable Process; Cytogenetic Evaluation of Telomere Dysfunction: Chromosomal Aberrations Involving Telomeres and Interstitial Telomeric Sequences; Telomeres -- Telomerase Biology and Their Role in Renal and Other Chronic Diseases; Telomerase and Telomere Dynamics in Cancer: Clinical Application for Cancer Diagnosis; Telomeres and Chromosome Segregation; Telomere-Based Genome-Protective Responses: A Mammalian Improvement on the Bacterial SOS Response?; Telomere Lengthening from Oocyte to Embryonic Stem Cell; Transcriptional Activity at the Telomeres of Chironomus (Diptera). Its Possible Role in the Lengthening of the Telomeres; Telomerase Activity: Application to Diagnosis of Human Carcinoma; Telomere Shortening in Diabetes Mellitus; Do Alterations in the Three-Dimensional Organization of Telomeres Indicate Malignant Transformation?; Telomeres: Function, Shortening and Lengthening; Telomerase Regulation in Stem Cells - How to Flip the Switch?; Telomeres: Function, Shortening and Lengthening "Telomere Maintenance Mechanisms in Bone and Soft Tissue Tumors"; Genetic Polymorphisms of Human Telomerase Reverse Transcriptase; Genetic Inhibition of Telomere Lengthening in Cancer Prevention and Treatment; Telomeres: Function, Shortening, and Lengthening; Clinical Implications of Telomerase Activity in Human Brain Tumors; Index.
| Erscheint lt. Verlag | 25.9.2009 |
|---|---|
| Zusatzinfo | Illustrations |
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 260 x 180 mm |
| Gewicht | 1190 g |
| Themenwelt | Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik |
| ISBN-10 | 1-60692-350-1 / 1606923501 |
| ISBN-13 | 978-1-60692-350-4 / 9781606923504 |
| Zustand | Neuware |
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