Searching for Molecular Solutions
John Wiley & Sons Inc (Verlag)
978-0-470-14682-8 (ISBN)
A comprehensive look at empirical approaches to molecular discovery, their relationships with rational design, and the future of both
Empirical methods of discovery, along with serendipitous and rational design approaches, have played an important role in human history. Searching for Molecular Solutions compares empirical discovery strategies for biologically useful molecules with serendipitous discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery.
Logically arranged, this text examines the different modes of molecular discovery, empha-sizing the historical and ongoing importance of empirical strategies. Along with a broad overview of the subject matter, Searching for Molecular Solutions explores:
The differing modes of molecular discovery
Biological precedents for evolutionary approaches
Directed evolutionary methods and related areas
Enzyme evolution and design
Functional nucleic acid discovery
Antibodies and other recognition molecules
General aspects of molecular recognition
Small molecule discovery approaches
Rational molecular design
The interplay between empirical and rational strategies and their ongoing roles in the future of molecular discovery
Searching for Molecular Solutions covers several major areas of modern research, development, and practical applications of molecular sciences. This text offers empirical-rational principles of broad relevance to scientists, professionals, and students interested in general aspects of molecular discovery, as well as the thought processes behind experimental approaches.
Ian S. Dunn, PhD, is the Director of Research at Cytocure, LLC, in Beverly, Massachusetts. In keeping with the scope of this book, he has a diverse background in immunology, cell and molecular biology, and biotechnology. His current research focuses on antigen gene regulation in melanoma cells.
Acknowledgments xi
Introduction xiii
1 If It Works, It Works: Pragmatic Molecular Discovery 1
2 Empirical Miracles: Nature's Precedents for Empirical Solutions 22
3 Evolution's Gift: Natural Somatic Diversification and Molecular Design 61
4 Evolution While You Wait 103
5 The Blind Protein Maker 145
6 The Blind Shaper of Nucleic Acids 187
7 Evolving and Creating Recognition Molecules 234
8 Molecules Small and Large 275
9 An Empirical--Rational Loop Forwards 315
10 Exploring the Limits 343
Glossary 365
Bibliography 374
References in Figure Legends 440
Index 443
| Erscheint lt. Verlag | 19.1.2010 |
|---|---|
| Zusatzinfo | Drawings: 40 B&W, 0 Color |
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 163 x 242 mm |
| Gewicht | 794 g |
| Einbandart | gebunden |
| Themenwelt | Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| ISBN-10 | 0-470-14682-6 / 0470146826 |
| ISBN-13 | 978-0-470-14682-8 / 9780470146828 |
| Zustand | Neuware |
| Haben Sie eine Frage zum Produkt? |
aus dem Bereich
