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Bioinformatics and Drug Discovery

Richard S. Larson (Herausgeber)

Buch | Hardcover

444 Seiten

2005
Humana Press Inc. (Verlag)
978-1-58829-346-6 (ISBN)

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A collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described.

New Strategies in Drug Discovery.- Basic Microarray Analysis.- From Microarray to Biological Networks.- Microarray Analysis in Drug Discovery and Clinical Applications.- Ontology-Driven Approaches to Analyzing Data in Functional Genomics.- Gene Evolution and Drug Discovery.- Standardization of Microarray and Pharmacogenomics Data.- Clinical Applications of Bioinformatics, Genomics, and Pharmacogenomics.- Protein Interactions Probed With Mass Spectrometry.- Discovering New Drug-Targeting Sites on Flexible Multidomain Protein Kinases.- Nuclear Magnetic Resonance-Based Screening Methods for Drug Discovery.- Receptor-Binding Sites.- In Silico Protein Design.- Chemical Database Preparation for Compound Acquisition or Virtual Screening.- Bioinformatics Platform Development.

"...succeeds admirably in illuminating the latest interdisciplinary techniques being applied to drug discovery, including target selection and validation, receptor binding site characterization and binding prediction, and use for new lead discovery." - Journal of Medicinal Chemistry

Erscheint lt. Verlag	1.10.2005
Reihe/Serie	Methods in Molecular Biology ; 316
Zusatzinfo	103 Illustrations, black and white; X, 444 p. 103 illus.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie ► PTA / PKA
	Technik
ISBN-10	1-58829-346-7 / 1588293467
ISBN-13	978-1-58829-346-6 / 9781588293466
Zustand	Neuware