Bayesian Adaptive Design for Immunotherapy and Targeted Therapy

Haitao Pan, Ying Yuan (Autoren)

Buch | Hardcover

262 Seiten

2023
Springer Verlag, Singapore
978-981-19-8174-6 (ISBN)

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This book provides a comprehensive review of novel adaptive trial designs for targeted therapies and immunotherapies. This book covers a wide range of novel statistical designs for various clinical settings, including early phase dose-escalation study, proof-of-concept trials, and confirmatory studies with registrational. The book includes real-life examples and software to facilitate practitioners to learn and use the designs in practice.

Introduction to Adaptive Design and Delayed Outcomes.- Basics of Bayesian Statistics.- Phase I Dose-finding Design.- Phase II Design for Interim Monitoring.- Phase I-II Dose-finding Design.- Drug Combination Trial Design.- Conclusion.

Erscheinungsdatum	22.04.2023
Zusatzinfo	50 Illustrations, color; 8 Illustrations, black and white; XI, 262 p. 58 illus., 50 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Mathematik / Informatik ► Mathematik ► Statistik
	Mathematik / Informatik ► Mathematik ► Wahrscheinlichkeit / Kombinatorik
	Medizin / Pharmazie ► Medizinische Fachgebiete
Schlagworte	Adaptive clinical trial design • Delayed outcomes • Late-onset outcomes • Markov Chain Monte Carlo (MCMC) method • Missing data analysis
ISBN-10	981-19-8174-4 / 9811981744
ISBN-13	978-981-19-8174-6 / 9789811981746
Zustand	Neuware