Epigenetics and Metabolomics

Paban K. Agrawala, Poonam Rana (Herausgeber)

Buch | Softcover

476 Seiten

2021
Academic Press Inc (Verlag)
978-0-323-85652-2 (ISBN)

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Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare.

Dr. Paban K. Agrawala Ph.D is a Scientist in the Radiation Epigenetics Division at the Institute of Nuclear Medicine and Allied Sciences in New Delhi, India, and previously was a Post doctoral Research Associate at Brookhaven National Lab, New York, USA. Dr. Agrawala is a member of the Indian Society for Radiation Biology, as well the Flowcytometry Society of India. He has published widely in such peer reviewed journals as the International Journal of Radiation Biology; Frontiers in Immunology; Current Topics in Medicinal Chemistry; and the Journal of Environmental Pathology, Toxicology, and Oncology. His current research focuses on understanding the epigenetic changes, especially histone acetyltion status, following exposure to ionizing radiation. Dr. Poonam Rana Phd is a Senior Scientist at the Institute of Nuclear Medicine & Allied Sciences, under Ministry of Defence, Delhi, India. She received her PhD at the CCS Haryana Agricultural University in Hisar, India. Her focus of research is applications of metabolomics and imaging in identification of biomarkers for traumatic brain injury and radiation exposure during combat emergencies. She has published widely in such peer reviewed journals as the Scientific Reports, Metabolomics, Journal of Neuroendocrinology, International Journal of Radiation Biology, Journal of Neuroscience Research, and Chemical Biological Interactions. Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.

1. Metabolomics techniques: A brief update
2. Integration of epigenomics and metabolomics: From biomarkers discovery to personalized medicine
3. Aging-associated changes in metabolic regulation of epigenetic modifications and gene expression
4. Epigenetic and metabolic changes in traumatic brain injury
5. Metabolic regulation in urological tumors: Interplay with epigenetics and epitranscriptomics
6. Multiomics approach for precision wellness
7. Oncogene: An epigenetic regulation
8. Epigenetic regulations in gastrointestine: Implications on sensitivity to ionizing radiation, inflammatory diseases, and cancer development
9. Epigenetics of epithelial to mesenchymal transition (EMT) in cancer
10. Nutrients seminal role in the development and epigenetic reprogramming during the first 1000 days of life
11. Epigenetic mechanisms of hepatocellular carcinoma progression: Potential therapeutic opportunities
12. Translational epigenetics in neurodegenerative diseases
13. Host-epigenetics-microbiota: A tripartite interaction in health and disease
14. Epigenetics in cardiovascular complications
15. Epigenetics and viral infectious diseases
16. Metabolic profiling leading to clinical phenomics: From bench to bedside
17. Epigenetic insights for wound healing mechanism
18. Role of metabolomics to investigate combined effect of radiation and burn
19. Advances and prospects of epigenetics in plants

Erscheinungsdatum	01.09.2021
Reihe/Serie	Translational Epigenetics
Mitarbeit	Herausgeber (Serie): Trygve Tollefsbol
Zusatzinfo	70 illustrations (30 in full color); Illustrations
Verlagsort	Oxford
Sprache	englisch
Maße	191 x 235 mm
Gewicht	910 g
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
Themenwelt	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	0-323-85652-7 / 0323856527
ISBN-13	978-0-323-85652-2 / 9780323856522
Zustand	Neuware