Bone Adaptation

In Silico Approach

Yoshitaka Kameo, Ken-ichi Tsubota, Taiji Adachi (Autoren)

Buch | Softcover

209 Seiten

2019 | Softcover reprint of the original 1st ed. 2018
Springer Verlag, Japan
978-4-431-56808-7 (ISBN)

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This book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics.

Overview: In Silico Approaches to Understand Bone Adaptation.- Microscopic Fluid Flow Analysis in an Osteocyte Canaliculus.- Macroscopic Fluid Flow Analysis in a Poroelastic Trabecula.- Estimation of Bone Permeability for Poroelastic Analysis.- Modeling Trabecular Bone Adaptation Induced by Flow Stimuli to Osteocytes.- Effects of Local Bending Load on Trabecular Bone Adaptation.- Cancellous Bone Adaptation Predicted by Remodeling Simulations.- Trabecular Surface Remodeling toward Uniform Local Stress State.- Spatial and Temporal Regulation of Cancellous Bone Structure by Trabecular Surface Remodeling.- Comparison of Mechanical Quantities as Bone Remodeling Stimuli.- Trabecular Surface Remodeling Simulation of Cancellous Bone Using Image-Based Voxel Finite Element Models.- Functional Adaptation of Cancellous Bone in Human Proximal Femur.- 3D Trabecular Remodeling in Human Proximal Femur: Approach to Understanding Wolff’s Law.- Trabecular Structural Changes in a Vertebral Body with a Fixation Screw.

Erscheinungsdatum	13.02.2019
Reihe/Serie	Frontiers of Biomechanics ; 2
Zusatzinfo	24 Illustrations, color; 69 Illustrations, black and white; XIV, 209 p. 93 illus., 24 illus. in color.
Verlagsort	Tokyo
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Mathematik / Informatik ► Mathematik ► Angewandte Mathematik
	Medizinische Fachgebiete ► Chirurgie ► Unfallchirurgie / Orthopädie
	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Technik ► Medizintechnik
Schlagworte	bone remodeling • Cellular Mechanosensing • functional adaptation • Hierarchical Bone Structure • Mechanotransduction • multiscale modeling • Wolff's Law
ISBN-10	4-431-56808-5 / 4431568085
ISBN-13	978-4-431-56808-7 / 9784431568087
Zustand	Neuware