Evolutionary Genomics

Statistical and Computational Methods

Buch | Hardcover

780 Seiten

2019 | 2nd ed. 2019
Humana Press Inc. (Verlag)
978-1-4939-9073-3 (ISBN)

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This open access book addresses the challenge of analyzing and understanding the evolutionary dynamics of complex biological systems at the genomic level, and elaborates on some promising strategies that would bring us closer to uncovering of the vital relationships between genotype and phenotype. After a few educational primers, the book continues with sections on sequence homology and alignment, phylogenetic methods to study genome evolution, methodologies for evaluating selective pressures on genomic sequences as well as genomic evolution in light of protein domain architecture and transposable elements, population genomics and other omics, and discussions of current bottlenecks in handling and analyzing genomic data. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and expert implementation advice that lead to the best results.
Authoritative and comprehensive, Evolutionary Genomics: Statistical and Computational Methods, Second Edition aims to serve both novices in biology with strong statistics and computational skills, and molecular biologists with a good grasp of standard mathematical concepts, in moving this important field of study forward.

Introduction to Genome Biology and Diversity.- Probability, Statistics, and Computational Science.- A Not-So-Long Introduction to Computational Molecular Evolution.- Whole-Genome Alignment.- Inferring Orthology and Paralogy.- Transposable Elements and Their Identification.- Modern Phylogenomics: Building Phylogenetic Trees Using the Multispecies Coalescent Model.- Genome-Wide Comparative Analysis of Phylogenetic Trees: The Prokaryotic Forest of Life.- The Methodology Behind Network-Thinking: Graphs to Analyze Microbial Complexity and Evolution.- Bayesian Molecular Clock Dating Using Genome-Scale Datasets.- Genome Evolution in Outcrossing vs. Selfing vs. Asexual Species.- Selection Acting on Genomes.- Looking for Darwin in Genomic Sequences: Validity and Success Depends on the Relationship between Model and Data.- Evolution of Viral Genomes: Interplay between Selection, Recombination, and Other Forces.- Evolution of Protein Domain Architectures.- New Insights on the Evolution of GenomeContent: Population Dynamics of Transposable Elements in Flies and Humans.- Association Mapping and Disease: Evolutionary Perspectives.- Ancestral Population Genomics.- Introduction to the Analysis of Environmental Sequences: Metagenomics with MEGAN.- Multiple Data Analyses and Statistical Approaches for Analyzing Data from Metagenomic Studies and Clinical Trials.- Systems Genetics for Evolutionary Studies.- Analyzing Epigenome Data in Context of Genome Evolution and Human Diseases.- Semantic Integration and Enrichment of Heterogeneous Biological Databases.- High-Performance Computing in Bayesian Phylogenetics and Phylodynamics Using BEAGLE.- Scalable Workflows and Reproducible Data Analysis for Genomics.- Sharing Programming Resources between Bio* Projects.

Erscheinungsdatum	15.03.2019
Reihe/Serie	Methods in Molecular Biology ; 1910
Zusatzinfo	110 Illustrations, color; 79 Illustrations, black and white; XVII, 780 p. 189 illus., 110 illus. in color. With online files/update.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Evolution
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
Schlagworte	Genome biology • Genotype and phenotype • Molecular data • Molecular Evolution • open access • probability and statistics • sequence homology
ISBN-10	1-4939-9073-X / 149399073X
ISBN-13	978-1-4939-9073-3 / 9781493990733
Zustand	Neuware