Advances in Nucleic Acid Therapeutics

Sudhir Agrawal, Michael J Gait (Herausgeber)

Buch | Hardcover

576 Seiten

2019
Royal Society of Chemistry (Verlag)
978-1-78801-209-6 (ISBN)

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The sequencing of the human genome and subsequent elucidation of the molecular pathways that are important in the pathology of disease have provided unprecedented opportunities for the development of new therapeutics. Nucleic acid-based drugs have emerged in recent years to yield extremely promising candidates for drug therapy to a wide range of diseases. Advances in Nucleic Acid Therapeutics is a comprehensive review of the latest advances in the field, covering the background of the development of nucleic acids for therapeutic purposes to the array of drug development approaches currently being pursued using antisense, RNAi, aptamer, immune modulatory and other synthetic oligonucleotides. Nucleic acid therapeutics is a field that has been continually innovating to meet the challenges of drug discovery and development; bringing contributions together from leaders at the forefront of progress, this book depicts the many approaches currently being pursued in both academia and industry. A go-to volume for medicinal chemists, Advances in Nucleic Acid Therapeutics provides a broad overview of techniques of contemporary interest in drug discovery.

History and Development of Nucleotide Analogues in Nucleic Acids Drugs;

Mechanisms of Antisense Oligonucleotides;

The Medicinal Chemistry of RNase H-activating Antisense Oligonucleotides;

Antisense Technology: Liver Targeting and Beyond for Drug Discovery;

Oligonucleotide-based Toll-like Receptor Antagonists and Therapeutic Applications;

Splicing Modulation for Therapeutics;

Targeting Toxic Repeats;

Research and Development of Oligonucleotides Targeting MicroRNAs (miRNAs);

Oligonucleotide Targeting of Long Non-coding RNAs;

Conjugate-mediated Delivery of RNAi-based Therapeutics: Enhancing Pharmacokinetics-Pharmacodynamics Relationships of Medicinal Oligonucleotides;

Liver-targeted RNAi Therapeutics: Principles and Applications;

Advances and Challenges of RNAi-Based Anti-HIV Therapeutics;

Nucleic Acid Innate Immune Receptors;

Synthetic Agonists of Toll-like Receptors and Therapeutic Applications;

Prostate-specific Membrane Antigen (PSMA) Aptamers for Prostate Cancer Imaging and Therapy;

Aptamers and Clinical Applications;

CRISPR-based Technologies for Genome Engineering: Properties, Current Improvements and Applications in Medicine;

Therapeutic Potential of Ribozymes;

Large-scale Automated Synthesis of Therapeutic Oligonucleotides: A Status Update;

Preclinical and Clinical Drug-metabolism, Pharmacokinetics and Safety of Therapeutic Oligonucleotides;

Subject Index

Erscheinungsdatum	20.02.2019
Reihe/Serie	Drug Discovery ; Volume 68
Verlagsort	Cambridge
Sprache	englisch
Maße	156 x 234 mm
Gewicht	993 g
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Chemie ► Organische Chemie
ISBN-10	1-78801-209-7 / 1788012097
ISBN-13	978-1-78801-209-6 / 9781788012096
Zustand	Neuware