Non-coding RNAs in Complex Diseases

A Bioinformatics Perspective

Xia Li, Juan Xu, Yun Xiao, Shangwei Ning, Yunpeng Zhang (Herausgeber)

Buch | Hardcover

126 Seiten

2018 | 1st ed. 2018
Springer Verlag, Singapore
978-981-13-0718-8 (ISBN)

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This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas.

Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.

Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.

Chapter 1. Non-coding RNA resources.- Chapter 2. Systematic identification of non-coding RNAs.- Chapter 3. Functional characterization of non-coding RNAs through genomic data fusion.- Chapter 4. Genomic-scale prioritization of disease-related non-coding RNAs.- Chapter 5. Genome-wide mapping of SNPs in non-coding RNAs.- Chapter 6. Profiling DNA methylation patterns of non-coding RNAs (ncRNAs) in human disease.- Chapter 7. Aberrant epigenetic modifications of non-coding RNAs in human disease.- Chapter 8. Computationally modeling ncRNA-ncRNA crosstalk.- Chapter 9. Computational inferring of risk subpathways mediated by dysfunctional non-coding RNAs.- Chapter 10. Computational identification of cross-talking ceRNAs.- Chapter 11. Prediction of non-coding RNAs as drug targets.- Chapter 12. Methods for Identification of Protein-RNA interaction.

Erscheinungsdatum	28.09.2018
Reihe/Serie	Advances in Experimental Medicine and Biology ; 1094
Zusatzinfo	37 Illustrations, color; 5 Illustrations, black and white; X, 126 p. 42 illus., 37 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	981-13-0718-0 / 9811307180
ISBN-13	978-981-13-0718-8 / 9789811307188
Zustand	Neuware