Molecular Modeling of Proteins

Buch | Softcover

474 Seiten

2017 | Softcover reprint of the original 2nd ed. 2015
Humana Press Inc. (Verlag)
978-1-4939-5491-9 (ISBN)

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Molecular Modeling of Proteins, Second Edition provides a theoretical background of various methods available and enables non-specialists to apply methods to their problems by including updated chapters and new material not covered in the first edition. This detailed volume opens by featuring classical and advanced simulation methods as well as methods to set-up complex systems such as lipid membranes and membrane proteins and continues with chapters devoted to the simulation and analysis of conformational changes of proteins, computational methods for protein structure prediction, usage of experimental data in combination with computational techniques, as well as protein-ligand interactions, which are relevant in the drug design process. Written for the highly successful Methods in Molecular Biology series, chapters include thorough introductions, step-by-step instructions and notes on troubleshooting and avoiding common pitfalls.

Update-to-date and authoritative, Molecular Modeling of Proteins, Second Edition aims to aid researchers in the physical, chemical and biosciences interested in utilizing this powerful technology.

Molecular Dynamics Simulations.- Transition Path Sampling with Quantum/Classical Mechanics for Reaction Rates.- Current Status of Protein Force Fields for Molecular Dynamics Simulations.- Lipid Membranes for Membrane Proteins.- Molecular Dynamics Simulations of Membrane Proteins.- Membrane-Associated Proteins and Peptides.- Coarse-Grained Force Fields for Molecular Simulations.- Tackling Sampling Challenges in Biomolecular Simulations.- Calculation of Binding Free Energies.- The Use of Experimental Structures to Model Protein Dynamics.- Computing Ensembles of Transitions with Molecular Dynamics Simulations.- Accelerated Molecular Dynamics and Protein Conformational Change: A Theoretical and Practical Guide Using a Membrane Embedded Model Neurotransmitter Transporter.- Simulations and Experiments in Protein Folding.- Comparative Modeling of Proteins.- De Novo Membrane Protein Structure Prediction.- NMR-Based Modeling and Refinement of Protein 3D Structures.- Methods for Predicting Protein Ligand Binding Sites.- Information-Driven Structural Modelling of Protein-Protein Interactions.- Identifying Putative Drug Targets and Potential Drug Leads: Starting Points for Virtual Screening and Docking.- Molecular Docking to Flexible Targets.

Erscheinungsdatum	23.03.2017
Reihe/Serie	Methods in Molecular Biology ; 1215
Zusatzinfo	53 Illustrations, color; 51 Illustrations, black and white; X, 474 p. 104 illus., 53 illus. in color.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Mathematik / Informatik ► Informatik ► Theorie / Studium
	Informatik ► Weitere Themen ► Bioinformatik
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	Biomolecule simulation • computational methods • Membrane Proteins • Molecular Modeling • Protein Structure Prediction • simulation methods
ISBN-10	1-4939-5491-1 / 1493954911
ISBN-13	978-1-4939-5491-9 / 9781493954919
Zustand	Neuware