Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems

Marc Thiriet (Autor)

Buch | Softcover

1064 Seiten

2016 | Softcover reprint of the original 1st ed. 2013
Springer-Verlag New York Inc.
978-1-4939-5207-6 (ISBN)

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The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning.

Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors. Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled. Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction.

1. Introduction.- 2. Signaling Lipids.- 3. Preamble to Cytoplasmic Protein Kinases.- 4. Cytoplasmic Protein Tyrosine Kinases.- 5. Cytoplasmic Protein Serine/Threonine Kinases.- 6. Dual-Specificity Protein Kinases.- 7. Mitogen-Activated Protein Kinase Module.- 8. Dual-Specificity Protein Kinases.- 9. Guanosine Triphosphatases and Their Regulators.- 10. Other Major Types of Signaling Mediators.- 11. Signaling Pathways.- 12. Conclusion.- References.- List of Currently Used Prefixes and Suffixes.- List of Aliases.-Complementary Lists of Notations.- Index.

Erscheinungsdatum	18.06.2016
Reihe/Serie	Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems ; 4
Zusatzinfo	XV, 1064 p.
Verlagsort	New York
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Mathematik / Informatik ► Mathematik ► Algebra
	Mathematik / Informatik ► Mathematik ► Angewandte Mathematik
	Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Naturwissenschaften ► Biologie
	Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
	Technik ► Maschinenbau
	Technik ► Medizintechnik
ISBN-10	1-4939-5207-2 / 1493952072
ISBN-13	978-1-4939-5207-6 / 9781493952076
Zustand	Neuware