Stress-Induced Mutagenesis
Springer-Verlag New York Inc.
978-1-4899-9418-9 (ISBN)
This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.
Preface.- Stress-induced mutagenesis in bacteria.- Mutagenesis Associated with Repair of DNA Double-Strand Breaks Under Stress.- Transcription-mediated mutagenic processes.- Transposon mutagenesis in disease, drug discovery and bacterial evolution.- Hsp90 as a capacitor of both genetic and epigenetic changes in the genome during cancer progression and evolution.- Inheritance of stress-induced epigenetic changes mediated by the ATF-2 family of transcription factors.- Microsatellite Repeats: Canaries in the Coalmine.- Genetic instability Induced by hypoxic stress.- Radiation-induced delayed genome Instability and hypermutation in mammalian cells.- Radiation-induced bystander effects and stress-induced mutagenesis.- Stress induced mutagenesis, genetic diversification, and cell survival via anastasis, the reversal of late stage apoptosis.- The transgenerational effects of parental exposure to mutagens in mammals.- Revisiting mutagenesis in the age of high-throughput sequencing.- Index.
Zusatzinfo | XV, 275 p. |
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Verlagsort | New York |
Sprache | englisch |
Maße | 155 x 235 mm |
Themenwelt | Informatik ► Weitere Themen ► Bioinformatik |
Medizin / Pharmazie ► Medizinische Fachgebiete | |
Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
Naturwissenschaften ► Biologie ► Biochemie | |
Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
ISBN-10 | 1-4899-9418-1 / 1489994181 |
ISBN-13 | 978-1-4899-9418-9 / 9781489994189 |
Zustand | Neuware |
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