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Optimized Response-Adaptive Clinical Trials

Sequential Treatment Allocation Based on Markov Decision Problems

Thomas Ondra (Autor)

Buch | Softcover

XV, 102 Seiten

2014 | 2015
Springer Fachmedien Wiesbaden GmbH (Verlag)
978-3-658-08343-4 (ISBN)

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Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.

Thomas Ondra obtained his Master of Science degree in mathematics at University of Vienna. He is a research assistant and PhD student at the Section for Medical Statistics of Medical University of Vienna.

Introduction to Markov Decision Problems and Examples.- Finite and Infinite Horizon Markov Decision Problems.- Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration.- Designing Response Adaptive Clinical Trials with Markov Decision Problems.

"It is a remarkably concise exposition of the use of MDPs in a pharmaceutical setting; as such, the book's audience is the intersection of researchers and students with a sophisticated mathematical background and professionals in the pharmaceutical industry. ... the book is a very sophisticated treatise on MDP models for managing response-adaptive clinical trials and both mathematicians and pharmaceutical professionals would appreciate it." (James Smith, Interfaces, Vol. 45 (4), July-August, 2015)

Erscheint lt. Verlag	18.12.2014
Reihe/Serie	BestMasters
Zusatzinfo	XV, 102 p. 14 illus.
Verlagsort	Wiesbaden
Sprache	englisch
Maße	148 x 210 mm
Gewicht	172 g
Themenwelt	Mathematik / Informatik ► Mathematik ► Analysis
Themenwelt	Mathematik / Informatik ► Mathematik ► Wahrscheinlichkeit / Kombinatorik
Schlagworte	Allocation Sequence • Analysis • Backward Induction • Clinical Trial Designs • Policy Iteration • Value Iteration
ISBN-10	3-658-08343-3 / 3658083433
ISBN-13	978-3-658-08343-4 / 9783658083434
Zustand	Neuware