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The Genetics of Obesity

Struan F.A. Grant (Herausgeber)

Buch | Hardcover

128 Seiten

2013 | 2014 ed.
Springer-Verlag New York Inc.
978-1-4614-8641-1 (ISBN)

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In the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO), h has been more robustly observed by others. Studies from both FTO knock out and FTO overexpression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity. Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book will give a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). This book will cover this state of the art technology and its application to obesity in great detail. Topics covered will include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants.

Genetic Variation and Obesity Prior to the Era of Genome-Wide Association Studies.- Genetic Obesity Syndromes.- Genome-Wide Association Studies of Obesity.- Copy Number Variants and their Contribution to the Risk of Obesity.- Genetics of Childhood Obesity.- Genetic Pleiotropies of Obesity.- Functional Follow-up of Genetic Variants Using FTO as the Prime Example.- Index.

Erscheint lt. Verlag	10.11.2013
Zusatzinfo	11 Illustrations, color; VIII, 128 p. 11 illus. in color.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	1-4614-8641-6 / 1461486416
ISBN-13	978-1-4614-8641-1 / 9781461486411
Zustand	Neuware