Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations (eBook)

Principles, Methods, and Applications in the Pharmaceutical Industry

Sheila Annie Peters (Autor)

eBook Download: PDF | EPUB

2012 | 1. Auflage
450 Seiten
John Wiley & Sons (Verlag)
978-1-118-14030-7 (ISBN)

Infos

The only book dedicated to physiologically-based pharmacokinetic
modeling in pharmaceutical science

Physiologically-based pharmacokinetic (PBPK) modeling has become
increasingly widespread within the pharmaceutical industry over the
last decade, but without one dedicated book that provides the
information researchers need to learn these new techniques, its
applications are severely limited. Describing the principles,
methods, and applications of PBPK modeling as used in
pharmaceutics, Physiologically-Based Pharmacokinetic (PBPK)
Modeling and Simulations fills this void.

Connecting theory with practice, the book explores the
incredible potential of PBPK modeling for improving drug discovery
and development. Comprised of two parts, the book first provides a
detailed and systematic treatment of the principles behind
physiological modeling of pharmacokinetic processes,
inter-individual variability, and drug interactions for small
molecule drugs and biologics. The second part looks in greater
detail at the powerful applications of PBPK to drug research.

Designed for a wide audience encompassing readers looking for a
brief overview of the field as well as those who need more detail,
the book includes a range of important learning aids. Featuring
end-of-chapter keywords for easy reference--a valuable asset
for general or novice readers without a PBPK background--along
with an extensive bibliography for those looking for further
information, Physiologically- Based Pharmacokinetic (PBPK) Modeling
and Simulations is the essential single-volume text on one of the
hottest topics in the pharmaceutical sciences today.

Autor

Sheila Annie Peters, PhD, is an Associate Principal Scientist for R&I DMPK at AstraZeneca. Previously, she was Principal Scientist at Cyprotex Discovery and lectured at the National Institute of Technology (Trichy, India), University of Madras, and Pondicherry University.

Rezensionen

"There is little to fault the book. ... [it] should be on
the shelf and a companion to anyone seriously interested in
mechanistic model-based drug development." (Nature
CPT, 10 July 2013)

"Peters does a credible job of bringing this huge area of
complex physiology and mathematics together."
(Pharmaceutical Journal, 21 July 2012)

Produkt-Details

• Erscheint lt. Verlag: 17.2.2012
• Sprache: englisch
• Themenwelt: Mathematik / Informatik ► Mathematik
• Themenwelt: Medizin / Pharmazie
• Themenwelt: Naturwissenschaften ► Chemie
• Schlagworte: Biostatistics • Biostatistik • Chemie • Chemistry • Drug Discovery & Development • Medical Science • Medizin • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Statistics • Statistik • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung
• ISBN-10: 1-118-14030-3 / 1118140303
• ISBN-13: 978-1-118-14030-7 / 9781118140307