MicroRNA let-7

Role in Human Diseases & Drug Discovery

Buch | Hardcover

154 Seiten

2012
Nova Science Publishers Inc (Verlag)
978-1-62081-152-8 (ISBN)

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MicroRNAs are small non-coding RNAs involved in post-transcriptional regulation of gene expression. Thousands of miRNAs have been identified in different organisms including viruses, insects, plants and animals. MiRNAs has emerged as key regulators of important biological processes. The differential expression of miRNAs in various human diseases has made them potential candidates for developing novel therapies and personalized medicines. This book is focused on microRNA let-7, the second miRNA discovered in the year 2000 and one of the most studied miRNA. This book discusses various aspects of miRNA let-7 starting from its discovery, biogenesis, transcriptional and posttranscriptional regulation to its crucial role in various fundamental cellular processes such as development, stem cell maintenance and differentiation, regulation of signalling pathways in cancer, drug resistance and therapeutic potential in different human diseases.

MicroRNA let-7: Discovery, Biogenesis, & General Function; Transcriptional & post-transcriptional regulation of let-7; Let-7 & signaling pathways in cancers; Role of let-7 networks in stem cell maintenance & differentiation; The role of microRNA let-7 in stem/progenitor cells; The impact of the let-7 family on resistance to anticancer treatment; Therapeutic Potential of miRNA let-7 in Human Diseases; Let-7 & Cancer; Roles of let-7 family miRNAs in development & differentiation.

Verlagsort	New York
Sprache	englisch
Maße	155 x 230 mm
Gewicht	466 g
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Medizin / Pharmazie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	1-62081-152-9 / 1620811529
ISBN-13	978-1-62081-152-8 / 9781620811528
Zustand	Neuware