Comparative Toxicogenomics (eBook)

Christer Hogstrand, Pete Kille (Herausgeber)

eBook Download: PDF

2008 | 1. Auflage
352 Seiten
Elsevier Science (Verlag)
978-0-08-056002-1 (ISBN)

Infos

"Toxicogenomics analyses the activity of a particular toxin or chemical substance on living tissue based upon a profiling of its known effects on genetic material. Toxicogenomics is important because it may enhance understanding of mechanisms of toxicity, cellular defence systems, and drug action. If this technique is proven to work, it could be used in a similar way for toxicology and toxin-determination to DNA-testing in the forensic identification of individuals.

Comparative Toxicogenomics provides a timely overview of current achievements and future areas of development including a review of some of the first really fruitful studies made in this area.

* Provides a review of some of the first really fruitful studies made in this area.

* Covers different organisms ranging from humans to model species and environmental sentinels so researchers can see how this technique has been used across different organisms and compare the results of each.

* The chapters transect research interests from identification of toxic action to environmental monitoring providing a broad view of the area increasing its attractiveness to researchers working in a variety of specialties."

---

Functional genomics has come of age. No longer is it an adventure for the avant garde scientist, but it has become an increasingly standardized mainstream tool accessible to any modern biological laboratory. Toxicogenomics studies are now generating an avalanche of data that, with the aid of established informatics methodology, is being translated into biologically meaningful information. This is enabling us to start harvesting the benefits from years of investment in terms of technology, time, and (of course) money. It is therefore timely to bring together leading toxicologists with a wide variety of scientific aims in this book to demonstrate how microarray technology can be successfully applied to different research areas. This book transects biology from bacteria to human, from ecologically relevant sentinel organisms to well-characterized model species, and represents the full toxicogenomics arena from exploratory "e;blue sky"e; science to the prospects for incorporation into regulatory frameworks. - Reviews some of the first really fruitful studies made in this area- Covers different organisms ranging from humans to model species and environmental sentinels- Provides a broad view of the area, increasing its attractiveness to researchers working in a variety of specialties

Inhalt

Cover 1
Copyright page 5
Information about the Society for Experimental Biology (SEB) 6
Advances in experimental biology 8
Information about the Series Editors 10
Information about the Volume Editors 12
List of Contributors 14
Preface 18
TOC$Contents 22
CH$Toxicogenomics: unlocking the potential of the human genome 24
Introduction 24
The current state of play in toxicogenomics 25
Toxicogenomics and personalised medical treatment 28
Bioinformatics 33
Environmental pollution and toxicogenomics 35
Toxicogenomics in the pharmaceutical industry: Drug candidate stratification 37
Conclusion 38
References 39
CH$Progress in ecotoxicogenomics for environmental monitoring, mode of action, and toxicant identification 44
Abbreviations 44
Introduction 46
’Omics’ as biomarkers 47
Potential applications of ecotoxicogenomics 62
Challenges 75
The need for standardisation and the role of consortiums 82
Conclusion 84
References 84
CH$Fish toxicogenomics 98
Introduction 99
Genomic resources for fish 103
Molecular biomarkers in fish 109
Mechanisms of toxicant action and biomarker discovery using genomics 115
Genetic fingerprints and profiles for chemicals in fish 119
Chemical mixtures 123
Phenotypic anchoring 124
Challenges in the interpretation of toxicogenomic data for fish 126
Good basic biology 133
Conclusions 135
Acknowledgements 136
References 136
CH$Current research in soil invertebrate ecotoxicogenomics 156
Introduction 156
Molecular genetic assays in soil invertebrates by single gene transcript quantification 158
Soil invertebrate transcriptomics 165
Soil invertebrate proteomics 171
Soil invertebrate metabolomics 173
Future perspectives in soil invertebrate ecotoxicogenomics 174
Acknowledgements 178
References 179
CH$Daphnia as an emerging model for toxicological genomics 188
The role Daphnia plays in toxicology 189
Daphnia genomics initiative 204
Concluding remarks 230
Acknowledgements 232
References 232
CH$Whole genome microarray analysis of the expression profile of Escherichia coli in response to exposure to para-nitrophenol 244
Introduction 245
Methods 248
Results and discussion 253
Acknowledgements 268
References 268
CH$Systems toxicology: using the systems biology approach to assess chemical pollutants in the environment 272
Introduction and aims 273
Control systems and the conception of systems biology 274
Current applications of Systems Biology 281
The application of systems toxicology to pollutants 289
Conclusions and recommendations 297
Appendix 1: Glossary of terms 299
References 301
Index of Authors 306
IDX$Subject Index 342
Color plate section 346

Produkt-Details

• Erscheint lt. Verlag: 11.7.2008
• Sprache: englisch
• Themenwelt: Informatik ► Weitere Themen ► Bioinformatik
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Ökologie / Naturschutz
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• Themenwelt: Technik
• ISBN-10: 0-08-056002-4 / 0080560024
• ISBN-13: 978-0-08-056002-1 / 9780080560021