Sequence Alignment

Methods, Models, Concepts, and Strategies

Buch | Softcover

360 Seiten

2011
University of California Press (Verlag)
978-0-520-27131-9 (ISBN)

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The sequencing of the human genome involved thousands of scientists but used relatively few tools. Obtaining sequences is simpler, but aligning the sequences remains a complicated but underappreciated aspect of comparative molecular biology. This book discusses the practice of alignment, and the procedures by which alignments are established.

The sequencing of the human genome involved thousands of scientists but used relatively few tools. Today, obtaining sequences is simpler, but aligning the sequences - making sure that sequences from one source are properly compared to those from other sources - remains a complicated but underappreciated aspect of comparative molecular biology. This volume, the first to focus on this crucial step in analyzing sequence data, is about the practice of alignment, the procedures by which alignments are established, and more importantly, how the outcomes of any alignment algorithm should be interpreted. Edited by Michael S. Rosenberg with essays by many of the field's leading experts, Sequence Alignment covers molecular causes, computational advances, approaches for assessing alignment quality, and philosophical underpinnings of the algorithms themselves.

Michael S. Rosenberg is Associate Professor of Computational Evolutionary Biology and Bioinformatics in the School of Life Sciences and the Center for Evolutionary Functional Genomics of the Biodesign Institute at Arizona State University.

Contributors Preface 1. Sequence Alignment: Concepts and History 2. Insertion and Deletion Events, Their Molecular Mechanisms, and Their Impact on Sequence Alignments 3. Local versus Global Alignments 4. Computing Multiple Sequence Alignment with Template-Based Methods 5. Sequence Evolution Models for Simultaneous Alignment and Phylogeny Reconstruction 6. Phylogenetic Hypotheses and the Utility of Multiple Sequence Alignment 7. Structural and Evolutionary Considerations for Multiple Sequence Alignment of RNA, and the Challenges for Algorithms That Ignore Them 8. Constructing Alignment Benchmarks 9. Simulation Approaches to Evaluating Alignment Error and Methods for Comparing Alternate Alignments Contents 10. Robust Inferences from Ambiguous Alignments 11. Strategies for Efficient Exploitation of the Informational Content of Protein Multiple Alignments References Index

Erscheint lt. Verlag	9.9.2011
Zusatzinfo	59 line illustrations, 13 tables
Verlagsort	Berkerley
Sprache	englisch
Maße	152 x 229 mm
Gewicht	467 g
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Naturwissenschaften ► Biologie ► Evolution
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	0-520-27131-9 / 0520271319
ISBN-13	978-0-520-27131-9 / 9780520271319
Zustand	Neuware