Numerical Methods for the Life Scientist
Binding and Enzyme Kinetics Calculated with GNU Octave and MATLAB
Seiten
2011
|
2011
Springer Berlin (Verlag)
978-3-642-20819-5 (ISBN)
Springer Berlin (Verlag)
978-3-642-20819-5 (ISBN)
This textbook provides a step-by-step introduction to numerical solutions of non-linear and differential equations. The text includes a set of programs to calculate any reaction scheme on any personal computer, as well as typical examples from various related fields.
Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.
Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.
Preparing the computer.- Binding equilibria.- Binding kinetics.- Least squares fit to experimental data.- Multi-parameter fits.- Comparing the two different approaches.
| Erscheint lt. Verlag | 6.8.2011 |
|---|---|
| Zusatzinfo | IX, 149 p. |
| Verlagsort | Berlin |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 375 g |
| Themenwelt | Informatik ► Weitere Themen ► Bioinformatik |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Schlagworte | advanced textbook • binding kinetics • biochemistry • Bioinformatik • dose-response curves • Enzyme kinetics • numerical solutions to reaction schemes |
| ISBN-10 | 3-642-20819-3 / 3642208193 |
| ISBN-13 | 978-3-642-20819-5 / 9783642208195 |
| Zustand | Neuware |
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